NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma

Autor: Rongfang Wei, Xing Cui, Jie Min, Zigen Lin, Yanyan Zhou, Mengjie Guo, Xiaojuan An, Hao Liu, Siegfried Janz, Chunyan Gu, Hongbo Wang, Ye Yang

Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 8, Pp 3313-3325 (2022)

Multiple myeloma (MM) is still an incurable hematologic malignancy, which is eagerly to the discovery of novel therapeutic targets and methods. N-acetyltransferase 10 (NAT10) is the first reported regulator of mRNA acetylation that is activated in ma

Externí odkaz: https://doaj.org/article/8e7e6fa4d4f04878a73a0b298aefe573

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Actin-dependent regulation of cilia length by the inverted formin FHDC1

Autor: John W. Copeland, Andrea McRae, Giulia Guarguaglini, Laura Trinkle-Mulcahy, Sarah J. Copeland

Publikováno v: Molecular biology of the cell 29 (2018): 1611–1627. doi:10.1091/mbc.E18-02-0088
info:cnr-pdr/source/autori:Copeland S.J.; McRae A.; Guarguaglini G.; Trinkle-Mulcahy L.; Copeland J.W./titolo:Actin-dependent regulation of cilia length by the inverted formin FHDC1/doi:10.1091%2Fmbc.E18-02-0088/rivista:Molecular biology of the cell/anno:2018/pagina_da:1611/pagina_a:1627/intervallo_pagine:1611–1627/volume:29

A primary cilium is found on most mammalian cells, where it acts as a cellular antenna for the reception of both mechanical and chemical signals. A variety of diseases are associated with defective ciliogenesis, reflecting the ubiquity of the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ba9464f8cf83182923e1217ada876c
https://doi.org/10.1091/mbc.e18-02-0088

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

Autor: Mark E. Burkard, B. Jack Longley, Maria Shabbir, Minakshi Nihal, Nihal Ahmad, Ryan A. Denu, Chandra K. Singh

Publikováno v: Molecular Cancer Research. 16:517-527

Centrosome amplification (CA) is common in cancer and can arise by centriole overduplication or by cell doubling events, including the failure of cell division and cell–cell fusion. To assess the relative contributions of these two mechanisms, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785c5bb758e79ebf5e40f102af37fb09
https://doi.org/10.1158/1541-7786.mcr-17-0197