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Akademický článek
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Akademický článek
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Autor:
Harry W. Schroeder
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/29544f6a1e6d4f88969d721525c12b9e
Autor:
Fang Ke, Zachary L Benet, Mitra P Maz, Jianhua Liu, Alexander L Dent, Joanne Michelle Kahlenberg, Irina L Grigorova
Publikováno v:
eLife, Vol 12 (2023)
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire
Externí odkaz:
https://doaj.org/article/859bb3259706499e8d6e931c50a4ed50
Autor:
Alessandra Noto, Madeleine Suffiotti, Victor Joo, Antonio Mancarella, Francesco A. Procopio, Guy Cavet, Yvonne Leung, Jean-Marc Corpataux, Matthias Cavassini, Agostino Riva, Leonidas Stamatatos, Raphael Gottardo, Adrian B. McDermott, Richard A. Koup, Craig Fenwick, Matthieu Perreau, Giuseppe Pantaleo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells. We have found that the expression of CXCR3 defines distinct Tfh subsets: CXCR3+ Th1
Externí odkaz:
https://doaj.org/article/f7bc6d2291a744dca296140e03ea8ac7
Autor:
Marc Descatoire, Remi Fritzen, Samuel Rotman, Genevieve Kuntzelman, Xavier Charles Leber, Stephanie Droz-Georget, Adrian J. Thrasher, Elisabetta Traggiai, Fabio Candotti
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110474- (2022)
Summary: A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to autoimmunity. A key contribution of B cells to development of these complications has been demonstrated through studies of samples from affected individuals and
Externí odkaz:
https://doaj.org/article/863a55212719468c9575a95c5d865b92
Autor:
Govindarajan Thangavelu, Michael C. Zaiken, Fathima A. Mohamed, Ryan Flynn, Jing Du, Stephanie Y. Rhee, Megan J. Riddle, Ethan G. Aguilar, Angela Panoskaltsis-Mortari, Martin E. Sanders, Bruce R. Blazar
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%–70% incidence of chronic graft-versus-host disease (cGVHD), a major cause of mortality and morbidity in long-term
Externí odkaz:
https://doaj.org/article/51fde4f6c3fd46bfa5dc1637b05aeb79
Autor:
Long Zheng, Xuanchuan Wang, Linkun Hu, Wenjun Gao, Weitao Zhang, Xuepeng Zhang, Chao Hu, Ruiming Rong, Cheng Yang, Dong Zhu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibody-mediated rejection (AMR) represents a major cause of allograft dysfunction and results in allograft failure in solid organ transplantation. Cyclic helix B peptide (CHBP) is a novel erythropoietin-derived peptide that ameliorated renal allogr
Externí odkaz:
https://doaj.org/article/04450554e9164c1f9547df67b1f253c4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T Follicular helper (Tfh) cells promote germinal center (GC) B cell responses to develop effective humoral immunity against pathogens. However, dysregulated Tfh cells can also trigger autoantibody production and the development of autoimmune diseases
Externí odkaz:
https://doaj.org/article/08682df6ced94001bc89e1530d67284d
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
B cell activation by Tfh cells, i.e., through CD154 engagement of CD40 and IL-21, and survival within GCs are crucial for the T-dependent Ab response. LUBAC, composed of HOIP, SHARPIN, and HOIL-1, catalyzes linear ubiquitination (Linear M1-Ub) to med
Externí odkaz:
https://doaj.org/article/5acafcf35eed4880b14b5d2c5ffb61c4