Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study.

Autor: Baranda, Joaquina C.¹ (AUTHOR) jbaranda@kumc.edu, Robbrecht, Debbie² (AUTHOR), Sullivan, Ryan³ (AUTHOR), Doger, Bernard⁴ (AUTHOR), Santoro, Armando^5,6 (AUTHOR), Barve, Minal⁷ (AUTHOR), Grob, Jean‐Jacques⁸ (AUTHOR), Bechter, Oliver⁹ (AUTHOR), Vieito, Maria¹⁰ (AUTHOR), de Miguel, Maria Jose¹¹ (AUTHOR), Schadendorf, Dirk¹² (AUTHOR), Johnson, Melissa¹³ (AUTHOR), Pouzin, Clemence¹⁴ (AUTHOR), Cantalloube, Cathy¹⁴ (AUTHOR), Wang, Rui¹⁵ (AUTHOR), Lee, Jooyun¹⁶ (AUTHOR), Chen, Xiaofei¹⁶ (AUTHOR), Demers, Brigitte¹⁷ (AUTHOR), Amrate, Amele¹⁷ (AUTHOR), Abbadessa, Giovanni¹⁶ (AUTHOR)

Publikováno v: CTS: Clinical & Translational Science. Jun2024, Vol. 17 Issue 6, p1-17. 17p.

Biomarker and pharmacodynamic activity of the transforming growth factor‐beta (TGFβ) inhibitor SAR439459 as monotherapy and in combination with cemiplimab in a phase I clinical study in patients with advanced solid tumors.

Autor: Robbrecht, Debbie¹ (AUTHOR), Grob, Jean‐Jacques² (AUTHOR), Bechter, Oliver³ (AUTHOR), Simonelli, Matteo^4,5 (AUTHOR), Doger, Bernard⁶ (AUTHOR), Borbath, Ivan⁷ (AUTHOR), Butler, Marcus O.⁸ (AUTHOR), Cheng, Tina⁹ (AUTHOR), Romano, Patricia Martin¹⁰ (AUTHOR), Pons‐Tostivint, Elvire¹¹ (AUTHOR), Di Nicola, Massimo¹² (AUTHOR), Curigliano, Giuseppe^13,14 (AUTHOR), Ryu, Min‐Hee¹⁵ (AUTHOR), Rodriguez‐Vida, Alejo¹⁶ (AUTHOR), Schadendorf, Dirk^17,18,19,20 (AUTHOR), Garralda, Elena²¹ (AUTHOR), Abbadessa, Giovanni²² (AUTHOR), Demers, Brigitte²³ (AUTHOR), Amrate, Amele²³ (AUTHOR), Wang, Hong²⁴ (AUTHOR)

Publikováno v: CTS: Clinical & Translational Science. Feb2024, Vol. 17 Issue 2, p1-11. 11p.

IL-6 as new prognostic factor in patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab.

Autor: Mallardo, Domenico¹ (AUTHOR), Simeone, Ester¹ (AUTHOR), Festino, Lucia¹ (AUTHOR), Tuffanelli, Marilena¹ (AUTHOR), Vanella, Vito¹ (AUTHOR), Trojaniello, Claudia¹ (AUTHOR), Vitale, Maria Grazia¹ (AUTHOR), Ottaviano, Margaret¹ (AUTHOR), Capone, Mariaelena¹ (AUTHOR), Madonna, Gabriele¹ (AUTHOR), Sparano, Francesca¹ (AUTHOR), Cioli, Eleonora¹ (AUTHOR), Scarpato, Luigi¹ (AUTHOR), Palla, Marco¹ (AUTHOR), Di Trolio, Rossella¹ (AUTHOR), Meinardi, Paolo¹ (AUTHOR), Caracò, Corrado¹ (AUTHOR), Ferrara, Gerardo¹ (AUTHOR), Muto, Paolo¹ (AUTHOR), Cavalcanti, Ernesta¹ (AUTHOR)

Publikováno v: Journal of Translational Medicine. 5/26/2023, Vol. 21 Issue 1, p1-6. 6p.

Long-term survival after anti-PD-1 discontinuation in advanced cutaneous squamous cell carcinoma (cSCC): a proof of concept of benefit of concomitant cemiplimab and radiotherapy.

Autor: Bailly-Caillé, Barbara¹ (AUTHOR), Levard, Romain¹ (AUTHOR) romain.levard@unicaen.fr, Kottler, Diane¹ (AUTHOR), Dompmartin, Anne¹ (AUTHOR), L'Orphelin, Jean-Matthieu^1,2 (AUTHOR) lorphelin-jm@chu-caen.fr

Publikováno v: Cancer Immunology, Immunotherapy. Jul2024, Vol. 73 Issue 7, p1-5. 5p.

Effective Management of Nasal Vestibule Squamous Cell Carcinoma with Cemiplimab: A Case Report.

Autor: Costabile, Ferdinando^1,2 (AUTHOR), Donnarumma, Marianna³ (AUTHOR), Piscosquito, Arianna¹ (AUTHOR), Ingenito, Concetta¹ (AUTHOR), Iuliucci, Michela Rosaria¹ (AUTHOR), Buonerba, Carlo^1,2 (AUTHOR), Di Lorenzo, Giuseppe^1,2 (AUTHOR), Di Trolio, Rossella⁴ (AUTHOR)

Publikováno v: Case Reports in Oncology. 2023, Vol. 16 Issue 1, p935-938. 4p.