Výsledky vyhledávání - "CELL NUCLEUS RECEPTOR"

Divergent modulation of proteostasis in prostate cancer

Autor: Kırmızıbayrak, Petek Ballar, Gözen, Oğuz, Erzurumlu, Yalçın, Barrio, R, Sutherland, JD, Rodriguez, MS

Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9458::9417a90ad155f532ada7c63e64bf5b99
http://hdl.handle.net/11452/30992

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Hunig's base catalyzed synthesis of new 1-(2,3-dihydro-1H-inden-1-yl)-3-aryl urea/thiourea derivatives as potent antioxidants and 2HCK enzyme growth inhibitors

Autor: Swetha Vallela, Visweswara Rao Pasupuleti, Grigoriy V. Zyryanov, Venkataramana Lachhi Reddy, Naga Raju Chamarthi, Jaya Shree Anireddy, Vijay Kumar Reddy Avula

Publikováno v: Bioorg. Chem.
Bioorganic Chemistry

A series of 1-(2,3-dihydro-1H-indan-1-yl)-3-aryl urea/thiourea derivatives (4a-j) have been synthesized from the reaction of 2,3-dihydro-1H-inden-1-amine (2) with various aryl isocyanates/isothiocyanates (3a-j) by using N,N-DIPEA base (Hunig's base)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc0762df3d5d57522edfdd207388aa1
https://pubmed.ncbi.nlm.nih.gov/31911311

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Natural helix 9 mutants of PPARγ differently affect its transcriptional activity

Autor: Broekema, Marjoleine F., Massink, Maarten P.G., Donato, Cinzia, de Ligt, Joep, Schaarschmidt, Joerg, Borgman, Anouska, Schooneman, Marieke G., Melchers, Diana, Gerding, Martin N., Houtman, René, Bonvin, Alexandre M.J.J., Majithia, Amit R., Monajemi, Houshang, van Haaften, Gijs W., Soeters, Maarten R., Kalkhoven, Eric, NMR Spectroscopy, Sub NMR Spectroscopy

Publikováno v: Molecular Metabolism, 20, 115. Elsevier GmbH
Molecular metabolism, 20, 115-127. Elsevier GmbH
Molecular Metabolism, Vol 20, Iss, Pp 115-127 (2019)
Molecular Metabolism

Objective The nuclear receptor PPARγ is the master regulator of adipocyte differentiation, distribution, and function. In addition, PPARγ induces terminal differentiation of several epithelial cell lineages, including colon epithelia. Loss-of-funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235707b80e74ebb76e89f9f074c1c68d
https://doi.org/10.1016/j.molmet.2018.12.005

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Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney

Autor: Jocelyne Aigueperse, Jean-Marc A. Lobaccaro, Patrick Gourmelon, Maâmar Souidi, Line Grandcolas, Yann Gueguen, E. Tissandie

Publikováno v: Journal of Steroid Biochemistry and Molecular Biology
Journal of Steroid Biochemistry and Molecular Biology, 2008, 110 (3-5), pp.263-268. ⟨10.1016/j.jsbmb.2007.11.002⟩

An increasing awareness of the radiological impact of the nuclear power industry and other nuclear technologies is observed nowadays on general population. This led to renew interest to assess the health impact of the use of enriched uranium (EU). Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204cca7d78e069693149e3820688b623
https://doi.org/10.1016/j.jsbmb.2007.11.002

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In vivo effects of chronic contamination with 137 cesium on testicular and adrenal steroidogenesis

Autor: Patrick Gourmelon, Elise Grignard, Jean-Marc A. Lobaccaro, Maamar Souidi, Stéphane Grison, Yann Gueguen

Publikováno v: Archives of Toxicology
Archives of Toxicology, 2008, 82 (9), pp.583-589. ⟨10.1007/s00204-007-0268-4⟩

More than 20 years after Chernobyl nuclear power plant explosion, radionuclides are still mainly bound to the organic soil layers. The radiation exposure is dominated by the external exposure to gamma-radiation following the decay of (137)Cs and by s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644927714928ba8c327f1ec41e5a750
https://doi.org/10.1007/s00204-007-0268-4

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Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor ?, ?, ? subtypes: An in silico approach

Autor: Sarath Josh, M.K., Pradeep, S., Vijayalekshmi Amma, K.S., Balachandran, S., Abdul Jaleel, U.C., Doble, M., Spener, F., Benjamin, S.

Publikováno v: IndraStra Global.

This exhaustive in silico study looks into the molecular interactions of phthalates and their metabolites with human peroxisome proliferator-activated receptor (hPPAR) and retinoid X receptor (hRXR) ?, ? and ? subtypes - the nuclear receptor proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=issn23813652::cbed98f0f71c299a77f3dd0ccd38daac
http://hdl.handle.net/11717/15361

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Intronic Elements In The Na+/I- Symporter Gene (Nis) Interact With Retinoic Acid Receptors And Mediate Initiation Of Transcription

Autor: Valeria Di Dato, Hani Alotaibi, Domenico Salvatore, Roberto Di Lauro, Uygar H. Tazebay, Elif Yaman, Pelin Telkoparan

Publikováno v: Nucleic Acids Research

Activity of the sodium/iodide symporter (NIS) in lactating breast is essential for iodide (I-) accumulation in milk. Significant NIS upregulation was also reported in breast cancer, indicating a potential use of radioiodide treatment. All-trans-retin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9ba3f2893ca8fc479a96c51e3d11ce
https://aperta.ulakbim.gov.tr/record/26871

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Placental steroids in cattle: hormones, placental growth factors or by-products of trophoblast giant cell differentiation?

Autor: G. R. Özalp, Gerhard Schuler, B. Döring, H. Greven, Bernd Hoffmann, Mariusz P. Kowalewski

Publikováno v: Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 116(7)

The bovine placenta produces large amounts of steroids, mainly estrone (E1) and progesterone (P-4). Specific features of bovine placental steroidogenesis are I) the expression of all enzymes needed for the production of estrogens from cholesterol in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1369c7249959845fd2a7e6018204fd3
https://pubmed.ncbi.nlm.nih.gov/18704836

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Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence

Autor: Bumaschny, V.F., De Souza, F.S.J., Leal, R.A.L., Santangelo, A.M., Baetscher, M., Levi, D.H., Low, M.J., Rubinstein, M.

Publikováno v: Mol. Endocrinol. 2007;21(11):2738-2749
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

The stress response involves complex physiological mechanisms that maximize behavioral efficacy during attack or defense and is highly conserved in all vertebrates. Key mediators of the stress response are pituitary hormones encoded by the proopiomel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::8b27c966394750a0e744bf380f96c5ff

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Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes

Autor: Presman, D.M., Hoijman, E., Ceballos, N.R., Galigniana, M.D., Pecci, A.

Publikováno v: Endocrinology 2006;147(11):5452-5459
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

The antiapoptotic effect of melatonin (MEL) has been described in several systems. In particular, MEL inhibits glucocorticoid-mediated apoptosis. Our group previously demonstrated that in the thymus, MEL inhibits the release of Cytochrome C from mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::4f41c7f8889fc4ec34ee8eb73724175e

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