Zobrazeno 1 - 10
of 25 549
pro vyhledávání: '"CELL FATE"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Pluripotent stem cells can differentiate into distinct cell types but the intracellular pathways controlling cell fate choice are not well understood. The social amoeba Dictyostelium discoideum is a simplified system to study choice preferen
Externí odkaz:
https://doaj.org/article/2ca891443ba543b091896f9d87053797
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7097-7113 (2024)
microRNAs (miRNAs) represent small RNA molecules involved in the regulation of gene expression. They are implicated in the regulation of diverse cellular processes ranging from cellular homeostasis to stress responses. Unintended irradiation of the c
Externí odkaz:
https://doaj.org/article/411ff98365e748ea9a43a6932378dfd2
Autor:
Chen He, Chen Hu, Wen-Zhen He, Yu-Chen Sun, Yangzi Jiang, Ling Liu, Jing Hou, Kai-Xuan Chen, Yu-Rui Jiao, Mei Huang, Min Huang, Mi Yang, Qiong Lu, Jie Wei, Chao Zeng, Guang-Hua Lei, Chang-Jun Li
Publikováno v:
Bioactive Materials, Vol 36, Iss , Pp 508-523 (2024)
Obesity-induced chronic inflammation exacerbates multiple types of tissue/organ deterioration and stem cell dysfunction; however, the effects on skeletal tissue and the underlying mechanisms are still unclear. Here, we show that obesity triggers chan
Externí odkaz:
https://doaj.org/article/4b0dfc5f16f44d35b8f1437bdfcf1ec5
Autor:
Jing Na, Zhijie Yang, Qiusheng Shi, Chiyu Li, Yu Liu, Yaxin Song, Xinyang Li, Lisha Zheng, Yubo Fan
Publikováno v:
Bioactive Materials, Vol 35, Iss , Pp 549-563 (2024)
The biophysical factors of biomaterials such as their stiffness regulate stem cell differentiation. Energy metabolism has been revealed an essential role in stem cell lineage commitment. However, whether and how extracellular matrix (ECM) stiffness r
Externí odkaz:
https://doaj.org/article/471db653544343119958dc09172e992b
Autor:
Sungkyu Lee, Jounghyun Yoo, Gunhyu Bae, Ramar Thangam, Jeongyun Heo, Jung Yeon Park, Honghwan Choi, Chowon Kim, Jusung An, Jungryun Kim, Kwang Rok Mun, Seungyong Shin, Kunyu Zhang, Pengchao Zhao, Yuri Kim, Nayeon Kang, Seong-Beom Han, Dahee Kim, Jiwon Yoon, Misun Kang, Jihwan Kim, Letao Yang, Solmaz Karamikamkar, Jinjoo Kim, Yangzhi Zhu, Alireza Hassani Najafabadi, Guosheng Song, Dong-Hwee Kim, Ki-Bum Lee, Soong Ju Oh, Hyun-Do Jung, Hyun-Cheol Song, Woo Young Jang, Liming Bian, Zhiqin Chu, Juyoung Yoon, Jong Seung Kim, Yu Shrike Zhang, Yongju Kim, Ho Seong Jang, Sehoon Kim, Heemin Kang
Publikováno v:
Bioactive Materials, Vol 34, Iss , Pp 164-180 (2024)
Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo+ self-assembly composed of azobenzene deriva
Externí odkaz:
https://doaj.org/article/e001e36b311a4a63a46fd305d4aac455
Autor:
Jin Zhang, Lingling Tong, Yuchen Liu, Xiang Li, Jiayi Wang, Ruoxin Lin, Ziyu Zhou, Yunbing Chen, Yanxi Chen, Yirong Liu, Di Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101199- (2024)
As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N6-methyladenosine (m6A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m6A modification is
Externí odkaz:
https://doaj.org/article/61c0d7e0e6d045f1be238f270384276c
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Hypertension affects one-third of the adult population worldwide, with primary aldosteronism (PA) accounting for at least 5-10% of these cases. The aldosterone synthase enzyme (CYP11B2) plays a pivotal role in PA manifestation, as increased expressio
Externí odkaz:
https://doaj.org/article/4d4ae6fdc7b84ba19ae243f08804095f
Publikováno v:
Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)
Aberrant oncogenic signaling causes cells to transition into oncogene-induced senescence (OIS) to limit uncontrolled proliferation. Despite being a potent tumor suppressor mechanism, OIS is an unstable cell state susceptible to reprogramming that can
Externí odkaz:
https://doaj.org/article/673b6c2c15db47e78bed38ee23becd4a
Autor:
Zan Li, Xiangchen Zeng, Baohong Shi, Jie Han, Zuoxing Wu, Xiaohui Chen, Long Zhang, Na Li, Matthew Greenblatt, Jianming Huang, Ren Xu
Publikováno v:
Journal of Orthopaedic Translation, Vol 45, Iss , Pp 168-177 (2024)
Background: Recently, the osteogenic potential of Adiponectin-labeled adipogenic lineage progenitors (Adipoq-lineage progenitors) in bone marrow has been observed to support bone maintenance and repair. However, little is known about the function of
Externí odkaz:
https://doaj.org/article/75782fd51e2d4ea3a96f825ff6144caa