Acquired angio-oedema caused by IgA paraprotein

Autor: D.J. van Spronsen, CE Hack, SJ Hoorntje, AJ Hannema

Publikováno v: The Netherlands Journal of Medicine. 52:22-25

The syndrome of acquired angio-oedema is characterized by late onset of recurrent bouts of angio-oedema or abdominal pain and may be caused by an acquired deficiency of C1-inhibitor (C1-INH), the inhibitor of the first component of complement. Acquir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616b4abeb86a2ed74d5a787cd48d0e66
https://doi.org/10.1016/s0300-2977(97)00066-1

Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees

Autor: van der Poll T, Levi M, Sj, Deventer, ten Cate H, Bart L. Haagmans, Bj, Biemond, Hr, Büller, Ce, Hack, Jw, Ten Cate

Publikováno v: Europe PubMed Central

Tumor necrosis factor (TNF) is considered to be a pivotal mediator of endotoxin-induced lethality. To assess the intermediate role of TNF in specific systemic inflammatory responses known to contribute to tissue injury in endotoxemia, eight healthy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1906d65e8c456232e2fd05a44e6b03e9
https://doi.org/10.1182/blood.v83.2.446.446

Identification of a putative binding site for negatively charged surfaces in the fibronectin type II domain of human factor XII-an immunochemical and homology modeling approach

Autor: Citarella F, te Velthuis H, Manuela Helmer-Citterich, Ce, Hack

Publikováno v: Citarella, F, te Velthuis, H, Helmer-Citterich, M & Hack, C E 2000, ' Identification of a putative binding site for negatively charged surfaces in the fibronectin type II domain of human factor XII-an immunochemical and homology modeling approach. ', Thrombosis and Haemostasis, vol. 84, no. 6, pp. 1057-65 .
Thrombosis and Haemostasis, 84(6), 1057-65. Schattauer GmbH
Europe PubMed Central

Monoclonal antibodies directed against functional sites of proteins provide useful tools for structure-function studies. Here we describe a mAb, KOK5, directed against the heavy chain region of human coagulation factor XII (FXII), which inhibits kaol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd8131f189f6fbb99f7a31f4698060a8
https://research.vumc.nl/en/publications/237cc63e-b897-4f65-bc97-95541e4b1d25

Monoclonal antibody F1 binds to the kringle domain of factor XII and induces enhanced susceptibility for cleavage by kallikrein

Autor: Dm, Ravon, Citarella F, Yt, Lubbers, BARBARA PASCUCCI, Ce, Hack

Publikováno v: Europe PubMed Central

In a previous study we have shown that monoclonal antibody F1 (MoAb F1), directed against an epitope on the heavy chain of factor XII distinct from the binding site for anionic surfaces, is able to activate factor XII in plasma (Nuijens JH, et al: J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fd07c4448f00dc82637b38550bd7a443
https://pubmed.ncbi.nlm.nih.gov/7492770

Clearance of human native, proteinase-complexed, and proteolytically inactivated C1-inhibitor in rats

Autor: BJ de Smet, JP de Boer, J Agterberg, G Rigter, WK Bleeker, CE Hack

Publikováno v: Blood. 81(1)

C1-inhibitor is the only known inhibitor of the classical pathway of complement and the major inhibitor of the contact pathway of coagulation. Like other serine proteinase inhibitors, C1-inhibitor can exist in three conformations, ie, the native, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11455c676744f1465116d5089df12c88
https://pubmed.ncbi.nlm.nih.gov/8417802