Zobrazeno 1 - 10
of 3 281
pro vyhledávání: '"CDK5"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) plays an essential role in glycolysis and in the antioxidant pathway associated with glutathione. Therefore, we investigated the effects of PFKFB3 on oxidative and ische
Externí odkaz:
https://doaj.org/article/6baf2fded24841ba9928a1baffd8af0e
Autor:
Jiejie Zhang, Shan Wang, Haitao Zhang, Xiaotong Yang, Xin Ren, Lei Wang, Yihan Yang, Yi Yang, Ya Wen
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract The aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple diseases including neurodegenerative diseases and cerebral ischemic injury. Previous studies have shown that depletion of mitochondrial NAD+, whic
Externí odkaz:
https://doaj.org/article/51b25f8766ba48aaa422fc9672ae9deb
Autor:
E. M. Kondaurova, A. A. Komarova, T. V. Ilchibaeva, A. Ya. Rodnyy, E. A. Zalivina, V. S. Naumenko
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 28, Iss 4, Pp 398-406 (2024)
Serotonin 5-HT7 receptors (5-HT7R) are attracting increasing attention as important participants in the mechanisms of Alzheimer’s disease and as a possible target for the treatment of various tau pathologies. In this study, we investigated the effe
Externí odkaz:
https://doaj.org/article/795e06d363584def8d839011eb131950
Autor:
Elizabeth Hernández-Echeagaray, Jorge A. Miranda-Barrientos, Elizabeth Nieto-Mendoza, Francisco Miguel Torres-Cruz
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Impaired mitochondrial function has been associated with the onset of neurodegenerative diseases. Specifically, certain mitochondrial toxins, such as 3-nitropropionic acid (3-NP), initiate cellular changes within the striatum that closely resemble th
Externí odkaz:
https://doaj.org/article/5b1e51c1f6a14ced9075022c1c8713e7
Autor:
Yingwei Huang, Qiqi Wang, Weiwei Zhou, Yawei Jiang, Kai He, Wei Huang, Yating Feng, Hong Wu, Lijuan Liu, Yue Pan, Yihua Huang, Zirui Chen, Wei Li, Yaowei Huang, Guanchuan Lin, Yulong Zhang, Yongyan Ren, Kaibiao Xu, Yanlin Yu, Yuping Peng, Xinghua Pan, Suyue Pan, Hailiang Hu, Yafang Hu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101054- (2024)
Aberrant expression of cyclin-dependent kinase 5 (Cdk5) has been reported in pituitary adenomas. However, the role of Cdk5 in the tumorigenesis remains unclear. We show that prenatal p25-activated Cdk5 phosphorylates minichromosome maintenance protei
Externí odkaz:
https://doaj.org/article/998382ff1fba495591fc69e85dc19626
Publikováno v:
Biology Open, Vol 13, Iss 10 (2024)
Externí odkaz:
https://doaj.org/article/f33d522eae174828ad3d6f0c831414d0
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Changes in neurovascular unit components and their interactions play a crucial role in epileptogenesis and the pathological process of epilepsy. Currently, there is a lack of animal models that can accurately reflect the etiological impact of cerebro
Externí odkaz:
https://doaj.org/article/1f4124b7ec5641c8b56d82cf68fbc641
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 2513-2530 (2024)
Yinan Cao,1– 3,* Fan Li,1– 3,* Zhenxuan Sun,1– 3 Jin Liu,1– 3 Jie Liu,1– 3 Qi Yang,1– 3 Peng Ge,1– 3 Yalan Luo,1– 3 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University,
Externí odkaz:
https://doaj.org/article/5c5f16982204480d9e3ae132b6268544
Autor:
Jana Ackmann, Alina Brüge, Lizaveta Gotina, Sungsu Lim, Kathrin Jahreis, Anna-Lena Vollbrecht, Yun Kyung Kim, Ae Nim Pae, Josephine Labus, Evgeni Ponimaskin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the microtubule-associated protein Tau leads to the development of so-called tauopathies characterized by the ag
Externí odkaz:
https://doaj.org/article/9432d306189d4856a2b79c4cb96775b0
Publikováno v:
Animal Bioscience, Vol 37, Iss 4, Pp 567-575 (2024)
Objective This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice. Methods The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high-throu
Externí odkaz:
https://doaj.org/article/806c10a87a514bbbb335469ef6e2a000