Zobrazeno 1 - 10
of 72
pro vyhledávání: '"CDCA - chenodeoxycholic acid"'
Autor:
Michael Goedken, Grace L. Guo, Brian Buckley, Bo Kong, Anita M. Brinker, Rulaiha Elizabeth Taylor, Daniel Rizzolo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3847-3856 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Bile acids (BAs) are amphipathic molecules important for metabolism of cholesterol, absorption of lipids and lipid soluble vitamins, bile flow, and regulation of gut microbiome. There are over 30 different BA species known to exist in humans and mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3528a74d648335c5d6495523367f011
http://www.sciencedirect.com/science/article/pii/S2211383521001891
http://www.sciencedirect.com/science/article/pii/S2211383521001891
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1789-1812 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d001e27a816f9de7d75ff16dd2143ec
http://www.sciencedirect.com/science/article/pii/S2211383520307279
http://www.sciencedirect.com/science/article/pii/S2211383520307279
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims The functions of the liver and the intestine are closely tied in both physiological and pathologic conditions. The gut microbiota (GM) often cause deleterious effects during hepatic pathogenesis. Autophagy is essential for liver hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5847c5c25a4c55b7146f469ae9e2e369
http://www.sciencedirect.com/science/article/pii/S2352345X20301740
http://www.sciencedirect.com/science/article/pii/S2352345X20301740
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1519-1539 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Nonalcoholic fatty liver disease comprises a wide spectrum of liver injuries from simple steatosis to steatohepatitis and cirrhosis. Nonalcoholic steatohepatitis (NASH) is defined when liver steatosis is associated with inflammation, hepatocyte damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f63dcdb7df5791629395e4c7c05eb5e
http://www.sciencedirect.com/science/article/pii/S2352345X21000187
http://www.sciencedirect.com/science/article/pii/S2352345X21000187
Autor:
Rumei, Li, Anna, Palmiotti, Hilde D, de Vries, Milaine V, Hovingh, Martijn, Koehorst, Niels L, Mulder, Yue, Zhang, Kim, Kats, Vincent W, Bloks, Jingyuan, Fu, Henkjan J, Verkade, Jan Freark, de Boer, Folkert, Kuipers
Publikováno v:
Journal of Lipid Research
Bile acids (BAs) play important roles in lipid homeostasis, and BA signaling pathways serve as therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Recently, we generated cytochrome P450, family 2, subfamily C, polypeptide 70 (Cyp2c70−
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df7ace3578bb12b2e9c95e117c5632a6
https://pubmed.ncbi.nlm.nih.gov/34626589
https://pubmed.ncbi.nlm.nih.gov/34626589
Autor:
Petia Shipkova, Giridhar S. Tirucherai, Arun J. Sanyal, Diane E. Shevell, Benjamin E. Decato, Colleen A. McNaney, Yi Luo, Edgar D. Charles, Abraham Apfel
Publikováno v:
JHEP Reports
Background & Aims Increased serum bile acids (BAs) have been observed in patients with non-alcoholic steatohepatitis (NASH). Pegbelfermin (PGBF), a polyethylene glycol-modified (PEGylated) analogue of human fibroblast growth factor 21 (FGF21), signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c523b47362c4cc87193b195c73edfb6d
https://pubmed.ncbi.nlm.nih.gov/34977519
https://pubmed.ncbi.nlm.nih.gov/34977519
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 2, Pp 235-246 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 2, Pp 235-246 (2019)
Bariatric surgery is the most effective and durable treatment for morbid obesity, with an unexplained yet beneficial side effect of restoring insulin sensitivity and improving glycemia, often before weight loss is observed. Among the many contributin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36ff49eff0989dc2bc68d2a48e2e1b8
https://doi.org/10.1016/j.jcmgh.2019.04.014
https://doi.org/10.1016/j.jcmgh.2019.04.014
Autor:
Spatz, Madeleine, Ciocan, Dragos, Merlen, Gregory, Rainteau, Dominique, Humbert, Lydie, Gomes-Rochette, Neuza, Hugot, Cindy, Trainel, Nicolas, Mercier-Nomé, Françoise, Domenichini, Séverine, Puchois, Virginie, Wrzosek, Laura, Ferrere, Gladys, Tordjmann, Thierry, Perlemuter, Gabriel, Cassard, Anne-Marie
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100230-(2021)
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100230. ⟨10.1016/j.jhepr.2021.100230⟩
JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100230. ⟨10.1016/j.jhepr.2021.100230⟩
JHEP Reports
Background & Aims Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes. We examined the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ae520b76500b6b211e8c427c2e781d78
http://www.sciencedirect.com/science/article/pii/S2589555921000069
http://www.sciencedirect.com/science/article/pii/S2589555921000069
Autor:
Grzych, Guillaume, Chavez-Talavera, Oscar, Descat, Amandine, Thuillier, Dorothee, Verrijken, An, Kouach, Mostafa, Legry, Vanessa, Verkindt, Helene, Raverdy, Violeta, Legendre, Benjamin, Caiazzo, Robert, Van Gaal, Luc, Goossens, Jean-Francois, Paumelle, Rejane, Francque, Sven, Pattou, Francois, Haas, Joel T., Tailleux, Anne, Staels, Bart
Publikováno v:
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100222-(2021)
JHEP Reports Innovation in Hepatology, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100222. ⟨10.1016/j.jhepr.2020.100222⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100222-(2021)
Background & Aims Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::74e69ecb4a62b415846d1ee012802a9c
https://www.hal.inserm.fr/inserm-03173334/document
https://www.hal.inserm.fr/inserm-03173334/document
Autor:
Höflinger, Philip, Hauser, Stefan, DeBarber, Andrea E, Martus, Peter, Lütjohann, Dieter, Griffiths, William J, Schöls, Ludger, Yutuc, Eylan, Hengel, Holger, Griffiths, Lauren, Radelfahr, Florentine, Howell, Owain W, Wang, Yuqin, Connor, Sonja L, Duell, P Barton
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100078-(2021)
Journal of lipid research 62, 100078-(2021). doi:10.1016/j.jlr.2021.100078
Journal of Lipid Research, Vol 62, Iss, Pp 100078-(2021)
Journal of lipid research 62, 100078-(2021). doi:10.1016/j.jlr.2021.100078
Cerebrotendinous xanthomatosis (CTX) is caused by autosomal recessive loss-of-function mutations in CYP27A1, a gene encoding cytochrome p450 oxidase essential for bile acid synthesis, resulting in altered bile acid and lipid metabolism. Here, we aime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b96bb91c97fb8b56ff512c91b7601958
https://pubmed.ncbi.nlm.nih.gov/33891937
https://pubmed.ncbi.nlm.nih.gov/33891937