Metalloprotease-mediated cleavage of CD95 Ligand

Autor: Vesna Risso, Mélissa Thomas, Blandine Guével, Regis Lavigne, Emmanuelle Com, Sophie Martin, Manon Nivet, Charles Pineau, Luc Negroni, Élodie Lafont, Éric Chevet, Leif A. Eriksson, Matthieu Le Gallo

Publikováno v: FEBS Journal
FEBS Journal, 2023, ⟨10.1111/febs.16737⟩

International audience; CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e89063653da47427c8766f8c744ca0
https://hal.science/hal-03968369

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Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Autor: Jean Levêque, Julien Corné, Matthieu Le Gallo, Patrick Legembre, Alain Fautrel, Marie Le Boulch, Aurélie Cauchois, Sébastien Henno, Bruno Laviolle, Vincent Lavoué, Estelle Le Pabic, Clotilde Poupon, Thibault De La Motte Rouge, Nathalie Rioux-Leclercq, Véronique Catros

Publikováno v: Molecular Cancer Research
Molecular Cancer Research, American Association for Cancer Research, 2019, 17 (12), pp.2537-2548. ⟨10.1158/1541-7786.MCR-19-0449⟩
Molecular Cancer Research, 2019, 17 (12), pp.2537-2548. ⟨10.1158/1541-7786.MCR-19-0449⟩

Soluble CD95L (s-CD95L) is a chemoattractant for certain lymphocyte subpopulations. We examined whether this ligand is a prognostic marker for high-grade serous ovarian cancer (HGSOC) and whether it is associated with accumulation of immune cells in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35481e0b529873385fa41970d434569e
https://pubmed.ncbi.nlm.nih.gov/31537619

Serum sCD95L concentration in patients with spinal cord injury

Autor: Axel Büchler, Christopher Child, Tyler Swing, Arash Moghaddam, Thomas Ferbert, Thomas Bruckner, H J Gerner, Harald Rief, Bahram Biglari, Tim Reitzel, Sebastian Korff, Elisabeth Biehl

Publikováno v: Journal of International Medical Research. 43:250-256

Objective To determine serum concentrations of soluble CD95 ligand (sCD95L) in patients with traumatic spinal cord injury. Methods Patients with traumatic spinal cord injury were recruited. Blood was collected on admission to hospital and at 4 h, 9 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b71d2ed3ef8e8e9543ad4858bca6d80
https://doi.org/10.1177/0300060514559794

P14.52 Differential methylation of a single CpG site in the CD95 ligand promoter affects gene activity and correlates with invasiveness of glioma cells

Autor: Benedikt Wiestler, J. Sykora, Andriy Krendyukov, C. Merz, C. Gieffers, Wolfgang Wick

Publikováno v: Neuro Oncol

BACKGROUND CD95 ligand (TNFSF6/APO-1L/FASLG) is a member of the Tumour Necrosis Factor Super Family (TNF-SF). Binding of the CD95 ligand (CD95L) to CD95 expressed on intrinsically apoptosis-resistant cancer cells like glioblastoma, triggers intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460c24b01de478f02d68821f52da51e6
https://doi.org/10.1093/neuonc/noz126.287