Zobrazeno 1 - 10
of 7 049
pro vyhledávání: '"CD8 + T cell"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Recent studies have identified SLC2A3 as being abnormally upregulated in multiple tumor types, correlating with poor survival and disrupted microenvironments. However, its prognostic significance in head and neck squamous cell carcinoma (HNS
Externí odkaz:
https://doaj.org/article/7d6ccc0fbf4a4117ab8f1083c16ef8a0
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Ferroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since its discovery in 2012, extensive research has demonstrated its pivotal roles in tumorigenesis, metastasis and cancer
Externí odkaz:
https://doaj.org/article/96bc0d999b4241dd835a92f917e2e947
Autor:
Sisi Zeng, Huiling Hu, Zhiyang Li, Qi Hu, Rong Shen, Mingzhou Li, Yunshi Liang, Zuokang Mao, Yandong Zhang, Wanqi Zhan, Qin Zhu, Feifei Wang, Jianbiao Xiao, Bohan Xu, Guanglong Liu, Yanan Wang, Bingsong Li, Shaowan Xu, Zhaowen Zhang, Ceng Zhang, Zhizhang Wang, Li Liang
Publikováno v:
Cancer Communications, Vol 44, Iss 11, Pp 1287-1310 (2024)
Abstract Background Dysfunction of CD8+ T cells in the tumor microenvironment (TME) contributes to tumor immune escape and immunotherapy tolerance. The effects of hormones such as leptin, steroid hormones, and glucocorticoids on T cell function have
Externí odkaz:
https://doaj.org/article/8f4ff07dafaf46e7bf37b3eed83a199c
Autor:
Quanlan Fu, Yuandong Luo, Junjie Li, Hejie Li, Xiaosong Liu, Zhu Chen, Guoying Ni, Tianfang Wang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Cancer immunotherapy, particularly immune checkpoint inhibitors (ICBs) such as anti-PD-1 antibodies, has revolutionised cancer treatment, although response rates vary among patients. Previous studies have demonstrated that caerin
Externí odkaz:
https://doaj.org/article/c04e3ce018cb49acbc9c5a968c9b61a4
Autor:
Yongfeng Wang, Yanzong Zhao, Guangming Zhang, Yifeng Lin, Chunling Fan, Hui Wei, Shude Chen, Ling Guan, Kan Liu, Shenhan Yu, Liangyin Fu, Jing Zhang, Yuan Yuan, Jin He, Hui Cai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Lymphocyte activating gene-3 (LAG3) is a distinctive T cell co-receptor that is expressed on the surface of lymphocytes. It plays a special inhibitory immune checkpoint role due to its unique domain and signaling pattern. Our aim is to explo
Externí odkaz:
https://doaj.org/article/43912141bdbf44bda946214736fc3bb9
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background We previously developed a nanobody targeting CTLA-4 and demonstrated that it can boost antitumour T-cell responses in vitro; however, the resulting responses after the injection of T cells into cancer models are usually weak and t
Externí odkaz:
https://doaj.org/article/1d9648289cd04c1d8d03e3f097f821bd
Autor:
Haodi Ma, LinLin Shi, Jiayu Zheng, Li Zeng, Youyou Chen, Shunshun Zhang, Siya Tang, Zhifeng Qu, Xin Xiong, Xuewei Zheng, Qinan Yin
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Breast cancer (BC) is the most common cancer in women and poses a significant health burden, especially in China. Despite advances in diagnosis and treatment, patient variability and limited early detection contribute to poor outc
Externí odkaz:
https://doaj.org/article/dcb219362b4648eab7a7e7c15a6987ae
Autor:
Zhouchi Yao, Yayun Zeng, Cheng Liu, Huimin Jin, Hong Wang, Yue Zhang, Chengming Ding, Guodong Chen, Daichao Wu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-30 (2024)
Abstract Vigorous CD8+ T cells play a crucial role in recognizing tumor cells and combating solid tumors. How T cells efficiently recognize and target tumor antigens, and how they maintain the activity in the “rejection” of solid tumor microenvir
Externí odkaz:
https://doaj.org/article/c159f7deadc24d5cbcbfdeed7b8a2bc0
Autor:
Bingyu Wang, Wenbo Liu, Mingming Zhang, Yong Li, Hongyue Tang, Yingying Wang, Chao Song, Buyun Song, Bibo Tan
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background While small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs) have been emerged as significant players in cancer, the function and underlying mechanism of sEVs-derived circRNAs in anti-cancer immunity remain unclear.
Externí odkaz:
https://doaj.org/article/d46d700692fd433ea7adddbd38bae2c3
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)
Abstract Tuberculosis is a serious global health burden, resulting in millions of deaths each year. Several circulating cell subsets in the peripheral blood are known to modulate the host immune response to Mycobacterium tuberculosis (Mtb) infection
Externí odkaz:
https://doaj.org/article/8cc4cfcce60b46dfa802e649c3ccf907