Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma

Autor: Chen Huang, Jin Shao, Jian Chen, Panpan Liang, Kai Zhang, Yufang Liu, Ruoyu Li, Zhen Su, Yubo Ma, Yi Zhang, Weiwei Deng, Xiao Liu

Publikováno v: Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 105-118 (2021)

CD8+ T cells are crucial to establish antitumor immunity, and their high infiltration associates with favorable prognoses. However, several CD8+ T cell subpopulations in the tumor microenvironment may play different roles in prognosis, progression, a

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http://www.sciencedirect.com/science/article/pii/S2372770520301753

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Single-cell RNA-sequencing analyses identify heterogeneity of CD8 ⁺ T cell subpopulations and novel therapy targets in melanoma.

Autor: Deng W; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Ma Y; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Su Z; Department of Dermatology and Venerology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China., Liu Y; Department of Dermatology and Venerology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China., Liang P; Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Huang C; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Liu X; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Shao J; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Zhang Y; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Zhang K; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China., Chen J; Department of Dermatology and Venerology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China., Li R; Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.; Research Center for Medical Mycology, Peking University, Beijing 100034, China.; Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Peking University First Hospital, Beijing, China.; National Clinical Research Center for Skin and Immune Diseases, Beijing, China.

Publikováno v: Molecular therapy oncolytics [Mol Ther Oncolytics] 2020 Dec 15; Vol. 20, pp. 105-118. Date of Electronic Publication: 2020 Dec 15 (Print Publication: 2021).