Zobrazeno 1 - 10
of 81
pro vyhledávání: '"CD8+ T cell differentiation"'
Akademický článek
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Autor:
Karthik Chandiran, Linda S. Cauley
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cytotoxic T lymphocytes (CTLs) play an important role in defense against infections with intracellular pathogens and anti-tumor immunity. Efficient migration is required to locate and destroy infected cells in different regions of the body. CTLs acco
Externí odkaz:
https://doaj.org/article/78a6df9f3d15407880c66a4dbec1bad2
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionImmunosuppressive therapy prevents graft rejection but increases the risk of non-melanoma skin cancer (NMSC), especially in elderly kidney transplant recipients (KTR).MethodsIn this study, we separately investigated the differentiation of
Externí odkaz:
https://doaj.org/article/7940558942c54ed88cff01d8a0d66b13
Autor:
Karthik Chandiran, Jenny E Suarez-Ramirez, Yinghong Hu, Evan R Jellison, Zeynep Ugur, Jun Siong Low, Bryan McDonald, Susan M Kaech, Linda S Cauley
Publikováno v:
eLife, Vol 11 (2022)
Transforming growth factor β (TGFβ) is an important differentiation factor for cytotoxic T lymphocytes (CTLs) and alters the expression levels of several of homing receptors during infection. SMAD4 is part of the canonical signaling network used by
Externí odkaz:
https://doaj.org/article/3e1aa3771a354027943ff186a8c20248
Autor:
Jonas Leonhard, Matthias Schaier, Florian Kälble, Volker Eckstein, Martin Zeier, Andrea Steinborn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chronic kidney failure (KF) provokes the development of immune senescent CD8+ cytotoxic T cells, affecting the occurrence of graft rejection, viral infections, and malignancies after kidney transplantation. In this study, we analyzed the impact of KF
Externí odkaz:
https://doaj.org/article/bb5e1071a98c43aebc4678581c0e77d7
Autor:
Vanessa Neitzke-Montinelli, Carolina Calôba, Guilherme Melo, Bianca B. Frade, Enzo Caramez, Luciano Mazzoccoli, André N. A. Gonçalves, Helder I. Nakaya, Renata M. Pereira, Miriam B. F. Werneck, João P. B. Viola
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Long-term immunological protection relies on the differentiation and maintenance of memory lymphocytes. Since the knowledge of memory generation has been centered on in vivo models of infection, there are obstacles to deep molecular analysis of diffe
Externí odkaz:
https://doaj.org/article/618a0bd1306c4679bcb6a137e9955e5c
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Nick P. Goplen, Su Huang, Bibo Zhu, In Su Cheon, Young Min Son, Zheng Wang, Chaofan Li, Qigang Dai, Li Jiang, Jie Sun
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tissue resident memory CD8 T cells (TRM) serve as potent local sentinels and contribute significantly to protective immunity against intracellular mucosal pathogens. While the molecular and transcriptional underpinnings of TRM differentiation are eme
Externí odkaz:
https://doaj.org/article/1218687dcd714673bfdf927a670ad903
Autor:
Fabienne Gräbnitz, Dominique Stark, Danielle Shlesinger, Anthony Petkidis, Mariana Borsa, Alexander Yermanos, Andreas Carr, Niculò Barandun, Arne Wehling, Miroslav Balaz, Timm Schroeder, Annette Oxenius
Publikováno v:
Cell Reports, 42 (5)
The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric cell division (ACD) as a safeguard mechanism for memory CD8 T cell gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94670db57a5bf39cddac06f7c032152f
