Výsledky vyhledávání - "CD4i antibodies"

Akademický článek

Antibody-Dependent Cellular Cytotoxicity-Competent Antibodies against HIV-1-Infected Cells in Plasma from HIV-Infected Subjects

Autor: Franck P. Dupuy, Sanket Kant, Alexandre Barbé, Jean-Pierre Routy, Julie Bruneau, Bertrand Lebouché, Cécile Tremblay, Marzena Pazgier, Andrés Finzi, Nicole F. Bernard

Publikováno v: mBio, Vol 10, Iss 6 (2019)

ABSTRACT Measuring Envelope (Env)-specific antibody (Ab)-dependent cellular cytotoxicity (ADCC)-competent Abs in HIV+ plasma is challenging because Env displays distinctive epitopes when present in a native closed trimeric conformation on infected ce

Externí odkaz: https://doaj.org/article/5431e290a44f41d0a90a711ffff01921

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Antibody-Dependent Cellular Cytotoxicity-Competent Antibodies against HIV-1-Infected Cells in Plasma from HIV-Infected Subjects

Autor: Julie Bruneau, Andrés Finzi, Alexandre Barbé, Bertrand Lebouché, Nicole F. Bernard, Sanket Kant, Franck P. Dupuy, Cécile Tremblay, Jean-Pierre Routy, Marzena Pazgier

Publikováno v: mBio, Vol 10, Iss 6, p e02690-19 (2019)
mBio
mBio, Vol 10, Iss 6 (2019)

HIV Env-specific nonneutralizing Abs (NnAbs) able to mediate ADCC have been implicated in protection from HIV infection. However, Env-specific NnAbs have the capacity to support ADCC of both HIV-infected and HIV-uninfected bystander cells, potentiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee31ba01143ca080142b6fdc32c4285
https://doaj.org/article/7f891915eccc4842a80df8c8cc471ea1

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Dissertation/ Thesis

Targeting the CD4- and Coreceptor-Binding Sites of the HIV-1 Envelope Glycoprotein

Autor: Gardner, Matthew Ryan

The HIV-1 envelope glycoprotein, Env, facilitates the translocation of the viral capsid across the cellular membrane. Env is a trimer of hetero-dimers composed of a gp120 subunit and gp41 transmembrane protein. The gp120 subunit binds the primary rec

Externí odkaz: http://dissertations.umi.com/gsas.harvard:11644
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274576

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Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains

Autor: Eric S. Rosenberg, James E. Robinson, Mariam Abreu, Chih Chin Huang, Joseph Sodroski, Liping Wang, Peter D. Kwong, Shi Hua Xiang

Publikováno v: Virology. 315(1)

Human immunodeficiency virus (HIV-1) enters target cells by binding its gp120 exterior envelope glycoprotein to CD4 and one of the chemokine receptors, CCR5 or CXCR4. CD4-induced (CD4i) antibodies bind gp120 more efficiently after CD4 binding and blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420502d67db40a6ce87e9b96c2d791e9
https://pubmed.ncbi.nlm.nih.gov/14592765

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