Bioengineer mesenchymal stem cell for treatment of glioma by IL‐12 mediated microenvironment reprogramming and nCD47‐SLAMF7 mediated phagocytosis regulation of macrophages

Autor: Man Li, Lisen Lu, Qungen Xiao, Ali Abdi Maalim, Bin Nie, Yanchao Liu, Ulf D. Kahlert, Kai Shu, Ting Lei, Mingxin Zhu

Publikováno v: Exploration, Vol 4, Iss 6, Pp n/a-n/a (2024)

Abstract High expression of cellular self‐activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors contributing to glioma's resistance to immunotherapy. Nonethel

Externí odkaz: https://doaj.org/article/1be42c1c24a94f7eb600bd0091a6ba0c

CD47 masks pro-phagocytic ligands in cison tumor cells to suppress antitumor immunity

Autor: Tang, Zhenghai, Zhong, Ming-Chao, Qian, Jin, Galindo, Cristian Camilo, Davidson, Dominique, Li, Jiaxin, Zhao, Yunlong, Hui, Enfu, Veillette, André

Publikováno v: Nature Immunology; 20230101, Issue: Preprints p1-10, 10p

CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity.

Autor: Tang Z; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada., Zhong MC; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada., Qian J; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada., Galindo CC; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada.; Department of Medicine, McGill University, Montréal, Québec, Canada., Davidson D; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada., Li J; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada.; Department of Medicine, McGill University, Montréal, Québec, Canada., Zhao Y; Department of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Hui E; Department of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA., Veillette A; Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada. andre.veillette@ircm.qc.ca.; Department of Medicine, McGill University, Montréal, Québec, Canada. andre.veillette@ircm.qc.ca.; Department of Medicine, University of Montréal, Montréal, Québec, Canada. andre.veillette@ircm.qc.ca.

Publikováno v: Nature immunology [Nat Immunol] 2023 Dec; Vol. 24 (12), pp. 2032-2041. Date of Electronic Publication: 2023 Nov 09.