Zobrazeno 1 - 10
of 188
pro vyhledávání: '"CD4-binding site"'
Autor:
Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, Peter D. Kwong
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody CAP256-VRC26.25 targets the second hypervariable region (V2) at the apex of the HIV envelope (Env) trimer with extraordinary neutralization potency, although less than optimal breadth. To improve breadth, we linked the light chain of
Externí odkaz:
https://doaj.org/article/bddbe9ec6f5b4b779bcbe4b49830cab8
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Peptide therapeutics have recently gained momentum in antiviral therapy due to their increased potency and cost-effectiveness. Interaction of the HIV-1 envelope gp120 with the host CD4 receptor is a critical step for viral entry, and therefore the CD
Externí odkaz:
https://doaj.org/article/7b18da89f68d40b8a0bea1437e752d62
Autor:
Tinashe E. Nyanhete, Robert J. Edwards, Celia C. LaBranche, Katayoun Mansouri, Amanda Eaton, S. Moses Dennison, Kevin O. Saunders, Derrick Goodman, Katarzyna Janowska, Rachel L. Spreng, Lu Zhang, Sarah V. Mudrak, Thomas J. Hope, Bhavna Hora, Todd Bradley, Ivelin S. Georgiev, David C. Montefiori, Priyamvada Acharya, Georgia D. Tomaras
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Broadly neutralizing antibodies (bNAbs), known to mediate immune control of HIV-1 infection, only develop in a small subset of HIV-1 infected individuals. Despite being traditionally associated with patients with high viral loads, bNAbs have also bee
Externí odkaz:
https://doaj.org/article/4c61ef5241d443e0b0ae4ef0bd8e6785
Autor:
Nneka Ugwu-Korie, Osbourne Quaye, Edward Wright, Sylvester Languon, Odame Agyapong, Emmanuel Broni, Yash Gupta, Prakasha Kempaiah, Samuel K. Kwofie
Publikováno v:
Molecules, Vol 28, Iss 2, p 474 (2023)
Broadly neutralizing antibodies (bNAbs) are potent in neutralizing a wide range of HIV strains. VRC01 is a CD4-binding-site (CD4-bs) class of bNAbs that binds to the conserved CD4-binding region of HIV-1 envelope (env) protein. Natural products that
Externí odkaz:
https://doaj.org/article/54c299fa218b4cbeae41fef4fbceed89
Autor:
William D. Tolbert, Dung N. Nguyen, Zahra Rikhtegaran Tehrani, Mohammad M. Sajadi, Marzena Pazgier
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The first step in HIV-1 entry is the attachment of the envelope (Env) trimer to target cell CD4. As such, the CD4-binding site (CD4bs) remains one of the few universally accessible sites for antibodies (Abs). We recently described a method o
Externí odkaz:
https://doaj.org/article/4c4bf6fd90634ed7ab385dfa192c5010
Autor:
Tongqing Zhou, Nicole A. Doria-Rose, Cheng Cheng, Guillaume B.E. Stewart-Jones, Gwo-Yu Chuang, Michael Chambers, Aliaksandr Druz, Hui Geng, Krisha McKee, Young Do Kwon, Sijy O’Dell, Mallika Sastry, Stephen D. Schmidt, Kai Xu, Lei Chen, Rita E. Chen, Mark K. Louder, Marie Pancera, Timothy G. Wanninger, Baoshan Zhang, Anqi Zheng, S. Katie Farney, Kathryn E. Foulds, Ivelin S. Georgiev, M. Gordon Joyce, Thomas Lemmin, Sandeep Narpala, Reda Rawi, Cinque Soto, John-Paul Todd, Chen-Hsiang Shen, Yaroslav Tsybovsky, Yongping Yang, Peng Zhao, Barton F. Haynes, Leonidas Stamatatos, Michael Tiemeyer, Lance Wells, Diana G. Scorpio, Lawrence Shapiro, Adrian B. McDermott, John R. Mascola, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 719-732 (2017)
While the HIV-1-glycan shield is known to shelter Env from the humoral immune response, its quantitative impact on antibody elicitation has been unclear. Here, we use targeted deglycosylation to measure the impact of the glycan shield on elicitation
Externí odkaz:
https://doaj.org/article/aabe08812b3841a8a0593b8fc0b38355
Autor:
Narayanaiah Cheedarla, Babu Hemalatha, Brahmaiah Anangi, Kannan Muthuramalingam, Murugesan Selvachithiram, Pattabiraman Sathyamurthi, Nandagopal Kailasam, Raghavan Varadarajan, Soumya Swaminathan, Srikanth Prasad Tripathy, S. Kalyanaraman Vaniambadi, D. Ramanathan Vadakkupattu, Luke Elizabeth Hanna
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterizati
Externí odkaz:
https://doaj.org/article/02ec40529aa24a7f93eebeab3b09316b
Autor:
Sanjeev Kumar, Rajesh Kumar, Lubina Khan, Muzamil Ashraf Makhdoomi, Ramachandran Thiruvengadam, Madhav Mohata, Mudit Agarwal, Rakesh Lodha, Sushil Kumar Kabra, Subrata Sinha, Kalpana Luthra
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Progression of human immunodeficiency virus type-1 (HIV-1) infection in children is faster than adults. HIV-1 subtype C is responsible for more than 50% of the infections globally and more than 90% infections in India. To date, there is no effective
Externí odkaz:
https://doaj.org/article/d999423940294be1b6161fef6c6a47c5
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