Zobrazeno 1 - 10
of 23 277
pro vyhledávání: '"CD4 T cells +"'
Autor:
Sho Ishigaki, Keiko Yoshimoto, Mitsuhiro Akiyama, Kotaro Matsumoto, Katsuya Suzuki, Kazuhiro Yamanoi, Yoichiro Iwakura, Tsutomu Takeuchi, Yuko Kaneko
Publikováno v:
Immunological Medicine, Pp 1-9 (2024)
Interleukin-1, a pro-inflammatory cytokine, plays a crucial role in inflammatory disease pathogenesis. Interleukin-1 receptor antagonist knockout (IL-1Ra KO) mice spontaneously develop aortitis, arthritis and dermatitis, and are employed as a model f
Externí odkaz:
https://doaj.org/article/71358403475a4dbbbbea7df7afe90091
Autor:
Ai-Sheng Ho, Jungshan Chang, Shou-Dong Lee, Zong-Lin Sie, Hui-Fen Shih, Chun Yeh, Cheng-Liang Peng, Kapil Dev, Chun-Chia Cheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Chronic hepatitis B (CHB) leads to liver inflammation and dysfunction, resulting in liver fibrosis and cancer. Nucleos(t)ide analogues (NAs), inhibitors of hepatitis B virus (HBV), specifically suppress HBV replication. We proposed that immu
Externí odkaz:
https://doaj.org/article/6d068a9de7234b309e2d80c12f855f0d
Publikováno v:
COVID, Vol 4, Iss 10, Pp 1676-1683 (2024)
Peptide p176-190, derived from the SARS-CoV-2 spike protein, is one of the major T cell epitopes that elicits the HLA-DR-restricted IL-8 response of human CD4+ T cells. Using PBMCs from a healthy individual primed with an S-protein-based SARS-CoV-2 v
Externí odkaz:
https://doaj.org/article/6f639598eb3e45faaef5bf7e8ad1b1f9
Autor:
Huy Quang Quach, Iana H. Haralambieva, Krista M. Goergen, Diane E. Grill, Jun Chen, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Older age (≥ 65 years) is associated with impaired responses to influenza vaccination, leading to the preferential recommendation of MF59-adjuvanted (MF59Flu) or high-dose (HDFlu) influenza vaccines for this age group in the United States.
Externí odkaz:
https://doaj.org/article/ce51629654d646adb5d67b575001e389
Autor:
Xiaodi Li, Ling Xu, Lianfeng Lu, Xiaosheng Liu, Yang Yang, Yuanni Wu, Ting Zhu, Xiaoxia Li, Yanling Li, Xiaojing Song, Yang Han, Wei Lyu, Wei Cao, Taisheng Li
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Several studies have reported that combination antiretroviral therapy (cART) enhances the hepatitis B surface antigen (HBsAg) clearance rate in Human Immunodeficiency Virus-1/Hepatitis B Virus (HIV/HBV) coinfected patients, yet th
Externí odkaz:
https://doaj.org/article/adfd764866b3485c804265ba9299c141
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background TK1 (Thymidine kinase 1) is a member of the thymidine kinase family and has been observed to be significantly upregulated in a variety of cancer types. However, the exact roles of TK1 in tumor progression and the tumor immune micr
Externí odkaz:
https://doaj.org/article/443c6bb5077740119a34ac3ff535238a
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Naïve CD4+ T cells and their differentiated counterparts play a significant regulatory role in the tumor immune microenvironment, yet their effects on lung adenocarcinoma (LUAD) are not fully understood. Methods We utilized Mende
Externí odkaz:
https://doaj.org/article/535d804a3a1541c5bfefac05d46a4e55
Autor:
Min Chen, Yingdi Meng, Xiaoqiong Shi, Chengjing Zhu, Minhui Zhu, Haihong Tang, Hongliang Zheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Several studies reveal that allergic rhinitis (AR) is a significant risk factor of systemic lupus erythematosus (SLE). However, studies investigating the common pathogenesis linking AR and SLE are lacking. Our study aims to search for the sh
Externí odkaz:
https://doaj.org/article/e7439e3118e74299b8e0aa59b7243d61
Autor:
Yun Wang, Rujia Chen, Zhenzhou Guo, Wei Wei, Ting Wang, Renren Ouyang, Xu Yuan, Yutong Xing, Feng Wang, Shiji Wu, Hongyan Hou
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Immune checkpoint inhibitors, such as anti-programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1) antibodies, have achieved breakthrough results in improving long-term survival rates in lung cancer. Although high levels of PD-L1
Externí odkaz:
https://doaj.org/article/eadd20ddd3ab463391562e0fdbbb38bd
Autor:
Marc Lauraine, Maxence de Taffin de Tilques, Dganit Melamed-Kadosh, Bilade Cherqaoui, Vincent Rincheval, Erwan Prevost, Aurore Rincheval-Arnold, Eneida Cela, Arie Admon, Isabelle Guénal, Luiza M. Araujo, Maxime Breban
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years, but still remains unexplained. We recently showed that HLA-B27 expressed in wing imaginal disc from HLA-B27/human-β2 microglobulin (hβ2m) transgeni
Externí odkaz:
https://doaj.org/article/3e9abc42338f4f889adf63c027a372f5