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Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

Autor: Wen Lin, Varan Singh, Raynel Springer, Gabrielle Choonoo, Namita Gupta, Aditi Patel, Davor Frleta, Jun Zhong, Tomasz Owczarek, Corinne Decker, Lynn Macdonald, Andrew Murphy, Gavin Thurston, Markus Mohrs, Ella Ioffe, Yi-Fen Lu

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here, we report potent CD4 T cell

Externí odkaz: https://doaj.org/article/64efdbe7ee8b495ea8268fb772fa6467

Rapamycin improves Graves’ orbitopathy by suppressing CD4+ cytotoxic T lymphocytes

Autor: Meng Zhang, Kelvin K.L. Chong, Zi-yi Chen, Hui Guo, Yu-feng Liu, Yong-yong Kang, Yang-jun Li, Ting-ting Shi, Kenneth K.H. Lai, Ming-qian He, Kai Ye, George J. Kahaly, Bing-yin Shi, Yue Wang

Publikováno v: JCI Insight, Vol 8, Iss 3 (2023)

CD4+ cytotoxic T lymphocytes (CTLs) were recently implicated in immune-mediated inflammation and fibrosis progression of Graves’ orbitopathy (GO). However, little is known about therapeutic targeting of CD4+ CTLs. Herein, we studied the effect of r

Externí odkaz: https://doaj.org/article/a0bdf2e55969476c83270a654f881efc

CD4 ⁺ Cytotoxic T Lymphocytes in Cancer Immunity and Immunotherapy.

Autor: Wang B; Thoracic Surgery Laboratory, Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, 430030, P. R. China., Hu S; Thoracic Surgery Laboratory, Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, 430030, P. R. China., Fu X; Thoracic Surgery Laboratory, Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, 430030, P. R. China., Li L; Thoracic Surgery Laboratory, Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, 430030, P. R. China.

Publikováno v: Advanced biology [Adv Biol (Weinh)] 2023 Apr; Vol. 7 (4), pp. e2200169. Date of Electronic Publication: 2022 Oct 04.

Antitumour activity mediated by CD4⁺ cytotoxic T lymphocytes against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12.

Autor: Homma, Sadamu¹ sahya@jikei.ac.jp, Komita, Hideo^1,2, Sagawa, Yukiko³, Ohno, Tsuneya¹, Toda, Gotaro²

Publikováno v: Immunology. Aug2005, Vol. 115 Issue 4, p451-461. 11p.