Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells

Autor: Marie de Bourayne, Sylvain Meunier, Samuel Bitoun, Evelyne Correia, Xavier Mariette, Hervé Nozach, Bernard Maillère

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Pegylation of biopharmaceuticals is the most common strategy to increase their half-life in the blood and is associated with a reduced immunogenicity. As antigen presentation is a primary event in the activation of CD4 T-cells and initiation of Anti-

Externí odkaz: https://doaj.org/article/1691747e1b1a4fa5b04d3fbcc5117f00

SARS-CoV-2 Evolution and Spike-Specific CD4+ T-Cell Response in Persistent COVID-19 with Severe HIV Immune Suppression

Autor: Hortensia Álvarez, Ezequiel Ruiz-Mateos, Pedro Miguel Juiz-González, Joana Vitallé, Irene Viéitez, María del Carmen Vázquez-Friol, Isabel Torres-Beceiro, Alberto Pérez-Gómez, Pilar Gallego-García, Nuria Estévez-Gómez, Loretta De Chiara, Eva Poveda, David Posada, Josep M. Llibre

Publikováno v: Microorganisms, Vol 10, Iss 1, p 143 (2022)

Intra-host evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported in cases with persistent coronavirus disease 2019 (COVID-19). In this study, we describe a severely immunosuppressed individual with HIV-1/SARS-CoV

Externí odkaz: https://doaj.org/article/c25d134b4c77454eb84f78708944c8ec

Correlates of Follicular Helper Bias in the CD4 T Cell Response to a Retroviral Antigen

Autor: Luca Danelli, Tiziano Donnarumma, George Kassiotis

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

CD4+ T cell differentiation is influenced by a plethora of intrinsic and extrinsic factors, providing the immune system with the ability to tailor its response according to specific stimuli. Indeed, different classes of pathogens may induce a distinc

Externí odkaz: https://doaj.org/article/a2954dbe424b4dbcb1addbce7a0bc21a

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity

Autor: Jodie Lopez, François Anna, Pierre Authié, Alexandre Pawlik, Min-Wen Ku, Catherine Blanc, Philippe Souque, Fanny Moncoq, Amandine Noirat, David Hardy, Wladimir Sougakoff, Roland Brosch, Françoise Guinet, Pierre Charneau, Laleh Majlessi

Publikováno v: Cell Reports
Cell Reports, 2022, 40 (4), pp.111142. ⟨10.1016/j.celrep.2022.111142⟩

International audience; Lentiviral vectors (LVs) are highly efficient at inducing CD8+ T cell responses. However, LV-encoded antigens are processed inside the cytosol of antigen-presenting cells, which does not directly communicate with the endosomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19035379ada3bffdacfa39659f1481f2
https://hal-pasteur.archives-ouvertes.fr/pasteur-03909608/file/1-s2.0-S2211124722009512-main.pdf

Introduction of non-natural amino acids into T-cell epitopes to mitigate peptide-specific T-cell responses

Autor: Azam, Aurélien, Mallart, Sergio, Illiano, Stephane, Duclos, Olivier, PRADES, Catherine, Maillère, Bernard

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, 12, pp.637963. ⟨10.3389/fimmu.2021.637963⟩
Frontiers in Immunology, Frontiers, 2021, 12, pp.637963. ⟨10.3389/fimmu.2021.637963⟩

International audience; Non-natural modifications are widely introduced into peptides to improve their therapeutic efficacy, but their impact on immunogenicity remains largely unknown. As the CD4 T-cell response is a key factor in triggering immunoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c472f323330715b4e751d6215b380062
https://hal.inrae.fr/hal-03321388