Zobrazeno 1 - 10
of 753
pro vyhledávání: '"CD200"'
Autor:
Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Human CD200R1 (hCD200R1), an immune inhibitory receptor expressed predominantly on T cells and myeloid cells, was identified as a promising immuno-oncology target by the 23andMe database. Blockade of CD200R1-dependent signaling enhances T cell-mediat
Externí odkaz:
https://doaj.org/article/c523efc8d50249edacd1a4181307eaa0
Autor:
Mohamed Ahmed, Liku B. Tezera, Nicholas Herbert, Mark Chambers, Michaela T. Reichmann, Kievershen Nargan, Henrik Kloverpris, Farina Karim, Mbali Hlatshwayo, Rajhmun Madensein, Munir Habesh, Monjural Hoque, Adrie J.C. Steyn, Paul T. Elkington, Alasdair J. Leslie
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by Mycobacterium tuberculosis (Mtb). However, pharmaceutical inhibition of T cell immune checkpoint molecules can result in the rapid devel
Externí odkaz:
https://doaj.org/article/ca0c40b9ed4b4e498de6ccb65ffb762b
Publikováno v:
Microorganisms, Vol 12, Iss 6, p 1185 (2024)
SARS-CoV-2, the pathogen causing COVID-19, continues to pose a significant threat to public health and has had major economic implications. Developing safe and effective vaccines and therapies offers a path forward for overcoming the COVID-19 pandemi
Externí odkaz:
https://doaj.org/article/7ed385d5552344c9a741312033270491
Autor:
Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang, Zhuang-Li Hu, Jian-Guo Chen
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its receptor CD200R1 is pri
Externí odkaz:
https://doaj.org/article/38e44c83736f4795924507022a86398f
Autor:
Yolanda Gonzalez-Montes, Gemma Osca-Gelis, Rocío Rodriguez-Romanos, Alicia Villavicencio, Marta González-Bártulos, Francesca Llopis, Victòria Clapes, Albert Oriol, Anna Sureda, Lourdes Escoda, Josep Sarrà, Ana Garzó, Natàlia Lloveras, Beatriz Gómez, Isabel Granada, David Gallardo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immune dysfunction in patients with MM affects both the innate and adaptive immune system. Molecules involved in the immune response pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. Howeve
Externí odkaz:
https://doaj.org/article/5c94d37e316b4400bb753f5edca4b0d9
Autor:
Afzal Misrani, Conelius Ngwa, Abdullah Al Mamun, Romana Sharmeen, Kanaka Valli Manyam, Rodney M. Ritzel, Louise McCullough, Fudong Liu
Publikováno v:
Brain Research Bulletin, Vol 207, Iss , Pp 110864- (2024)
Ischemic stroke induced inflammatory responses contribute significantly to neuronal damage and stroke outcomes. CD200 ligand and its receptor, CD200R, constitute an endogenous inhibitory signaling that is being increasingly recognized in studies of n
Externí odkaz:
https://doaj.org/article/8edfead9bf6042f38650d8f14ddb892d
Autor:
Jill Fenaux, Xin Fang, Yao-ming Huang, Cristina Melero, Caroline Bonnans, Earth Light Lowe, Tiziana Palumbo, Cecilia Lay, Zuoan Yi, Aileen Zhou, Mauro Poggio, Wei-Jen Chung, Sophia R. Majeed, Dylan Glatt, Alice Chen, Maike Schmidt, Clarissa C. Lee
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTImmune checkpoint inhibition (ICI) has revolutionized cancer treatment; however, only a subset of patients benefit long term. Therefore, methods for identification of novel checkpoint targets and development of therapeutic interventions again
Externí odkaz:
https://doaj.org/article/5b1a4e2f8e6a433f9b2901ba88665afe
Publikováno v:
Dermatology and Therapy, Vol 13, Iss 5, Pp 1171-1192 (2023)
Abstract Background There are a lot of studies that describe the change in quantity of T cells in patients with atopic dermatitis (AD) compared with healthy subjects. Other components of lymphocytes such as B cells are not examined as well as T cells
Externí odkaz:
https://doaj.org/article/4d88e37202b34107a586bedc0b32788a
Publikováno v:
Zhongguo linchuang yanjiu, Vol 36, Iss 2, Pp 252-257 (2023)
Objective To explore the role of CD200 in Ewing's sarcoma and its possible pathological mechanisms, and to search for potential drugs that can improve the survival prognosis of Ewing's sarcoma patients. Methods The RNA seq and clinical data of Ewing'
Externí odkaz:
https://doaj.org/article/72546722754a4ce1b6d55387400430b9
Autor:
Pavuluri Divya, Navatha Vangala, Megha S Uppin, Shantveer G Uppin, Sadashivudu Gundeti, Srinivas Bacchu, K K Radhika, A Parvathi, Tara Roshni Paul
Publikováno v:
Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 16, Iss 7, Pp 80-86 (2023)
Background: The cluster of differentiation 200 (CD200) is a recently introduced marker, used to differentiate various lymphoproliferative disorders (LPDs) and is a potential target for chemotherapy. Objective: The objective is to study the utility of
Externí odkaz:
https://doaj.org/article/c09b529086024cbf9df3bc9a4d553797