Zobrazeno 1 - 10
of 2 583
pro vyhledávání: '"CD154"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As part of our work to develop small-molecule inhibitors (SMIs) of the CD40-CD40L(CD154) costimulatory protein-protein interaction, here, we describe the ability of two of our most promising SMIs, DRI-C21041 and DRI-C21095, to prolong the survival an
Externí odkaz:
https://doaj.org/article/b9934ccfe1794acfa9cccb4774a29d1d
Publikováno v:
Cells, Vol 13, Iss 19, p 1621 (2024)
CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40. The CD154/CD40 dyad is a key participant in the pathogenesis of many autoimmune diseases,
Externí odkaz:
https://doaj.org/article/dba2cc506a474d07820e4d23837e8c67
Akademický článek
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Autor:
Nathalie Babl, Joshua Hofbauer, Carina Matos, Florian Voll, Ayse Nur Menevse, Michael Rechenmacher, Ruth Mair, Philipp Beckhove, Wolfgang Herr, Peter J. Siska, Kathrin Renner, Marina Kreutz, Annette Schnell
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows sufficient response to therapy. Hence, there is a n
Externí odkaz:
https://doaj.org/article/665d9c3a8e194fc4aff448d9891a418f
Autor:
Julia Strandmark, Alansana Darboe, Joann Diray-Arce, Rym Ben-Othman, Sofia M. Vignolo, Shun Rao, Kinga K. Smolen, Geert Leroux-Roels, Olubukola T. Idoko, Guzmán Sanchez-Schmitz, Al Ozonoff, Ofer Levy, Tobias R. Kollmann, Arnaud Marchant, Beate Kampmann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibod
Externí odkaz:
https://doaj.org/article/18f04a70e1674e919905aded5c30ad0c
Autor:
Alexandra Polakova, Leonie Kauter, Adina Ismagambetova, Dario Didona, Farzan Solimani, Kamran Ghoreschi, Michael Hertl, Christian Möbs, Christoph Hudemann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Analysis of T lymphocyte proliferation and activation after antigenic or mitogenic stimulation is a vital parameter used in the diagnosis of various immuno-deficiencies and during the monitoring of treatment responses. Most applied techniques are bas
Externí odkaz:
https://doaj.org/article/d9709003ca344348a6e3996d8dd71d55
Akademický článek
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Autor:
Steven Perrin, Marianne Magill
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The prevention of allograft transplant rejection by inhibition of the CD40/CD40L costimulatory pathway has been described in several species. We searched pubmed for studies reporting the prevention of kidney transplant rejection in nonhuman primates
Externí odkaz:
https://doaj.org/article/30a1f8c068914e44bb5d1b9cf060ccd8
Autor:
Ning Su, Chong-bin Hu, Tong Shao, Chun-yu Jin, Hao Li, Jian-fei Ji, Lu-lu Qin, Dong-Dong Fan, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao
Publikováno v:
Fish and Shellfish Immunology Reports, Vol 2, Iss , Pp 100038- (2021)
CD40 and CD154 are one of the best-characterized costimulatory molecules essential for adaptive immunity, which extensively involved in T and B cell activation, IgM Ab production, isotype class switching, germinal center formation and affinity matura
Externí odkaz:
https://doaj.org/article/633b795073464be594dcb17b8416ba31
Akademický článek
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