G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment

Autor: Martinez Sanz, Paula, van Rees, Dieke J, van Zogchel, Lieke M J, Klein, Bart, Bouti, Panagiota, Olsman, Hugo, Schornagel, Karin, Kok, Ivana, Sunak, Ali, Leeuwenburg, Kira, Timmerman, Ilse, Dierselhuis, Miranda P, Kholosy, Waleed M, Molenaar, Jan J, van Bruggen, Robin, van den Berg, Timo K, Kuijpers, Taco W, Matlung, Hanke L, Tytgat, Godelieve A M, Franke, Katka, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for ImmunoTherapy of Cancer, 9(5), 1. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 9(5), 1. BioMed Central
Journal for immunotherapy of cancer, 9(5):e002259. BioMed Central Ltd.

BackgroundCurrent immunotherapy for patients with high-risk neuroblastoma involves the therapeutic antibody dinutuximab that targets GD2, a ganglioside expressed on the majority of neuroblastoma tumors. Opsonized tumor cells are killed through antibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a8c22e38a8b458ee9e9cfac080fa47
https://doi.org/10.1136/jitc-2020-002259

Transcriptional regulation of murine natural killer cell development, differentiation and maturation

Autor: Held, W., Jeevan-Raj, B., Charmoy, M.

Publikováno v: Cellular and molecular life sciences, vol. 75, no. 18, pp. 3371-3379

Natural killer (NK) cells are innate cytotoxic effector cells that play important protective roles against certain pathogens as well as against pathogen-infected and transformed host cells. NK cells continuously arise from adult bone marrow-resident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::0cbfb7fba55da5e0c25e814f46f3e612
https://serval.unil.ch/notice/serval:BIB_1E93DC8609A6

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

Autor: Jutte van der Werff ten Bosch, Taco W. Kuijpers, Takashi Matozaki, Michel van Houdt, Dieke J van Rees, Paul Kubes, René A. W. van Lier, Catharina W Menke-van der Houven van Oordt, Jeanette H. W. Leusen, Paul Verkuijlen, Katka Franke, Xi Wen Zhao, Liane Babes, Jaap Jan Boelens, Karin Schornagel, Eiji Suzuki, Sergio Rutella, Karl Seeger, Hanke L. Matlung, Hans Janssen, Cor Lieftink, Roderick L. Beijersbergen, Dirk Roos, Louise W. Treffers, Ingrid Kühnle, Timo K. van den Berg, Daria Pagliara, Robin van Bruggen, Pasi Halonen

Publikováno v: Cell Reports, 23(13), 3946. Cell Press
Cell Reports, Vol 23, Iss 13, Pp 3946-3959.e6 (2018)
Cell reports, 23(13), 3946-3959.e6. Cell Press
Cell Reports, 23(13), 3946-3959.e6. Cell Press
Matlung, H L, Babes, L, Zhao, X W, van Houdt, M, Treffers, L W, van Rees, D J, Franke, K, Schornagel, K, Verkuijlen, P, Janssen, H, Halonen, P, Lieftink, C, Beijersbergen, R L, Leusen, J H W, Boelens, J J, Kuhnle, I, van der Werff Ten Bosch, J, Seeger, K, Rutella, S, Pagliara, D, Matozaki, T, Suzuki, E, Menke-van der Houven van Oordt, C W, van Bruggen, R, Roos, D, van Lier, R A W, Kuijpers, T W, Kubes, P & van den Berg, T K 2018, ' Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis ', Cell Reports, vol. 23, no. 13, pp. 3946-3959.e6 . https://doi.org/10.1016/j.celrep.2018.05.082

Summary: Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc-receptor-expressing immune cells, including neutrophils. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea52655291535ae8ca11d53102ba828
https://doi.org/10.1016/j.celrep.2018.05.082

Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain

Autor: Martin Wirenfeldt, Mads D. Pedersen, Paul Cumming, Bente Finsen, Michael Meldgaard, Luciano Minuzzi, Carina Slidsborg

Publikováno v: Pedersen, M D, Minuzzi, L, Wirenfeldt, M, Madsen, T M, Slidsborg, C, Cumming, P & Finsen, B 2006, ' Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain ', Eur. J. Neurosci., no. 24, pp. 991-1000 .
Pedersen, M D, Minuzzi, L, Wirenfeldt, M, Meldgaard, M, Slidsborg, C, Cumming, P & Finsen, B 2006, ' Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain ', European Journal of Neuroscience, vol. 24, no. 4, pp. 991-1000 . https://doi.org/10.1111/j.1460-9568.2006.04975.x

Increased binding of the peripheral benzodiazepine binding site (PBBS) ligand [(3)H]PK11195 in the central nervous system of patients suffering from acute and chronic neuropathology has been associated with reactive microgliosis. However, it remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8181f9be688b0e27fc1431571f3bb826
https://doi.org/10.1111/j.1460-9568.2006.04975.x