Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment

Autor: Alberto Pla-López, Miguel Carda, Eva Falomir

Publikováno v: Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115668- (2023)

Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine electron-donor or nitro el

Externí odkaz: https://doaj.org/article/26ae1b6e8122441087f16eb0c0889a5b

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Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME)

Autor: Reid, Tony, Oronsky, Bryan, Caroen, Scott, Quinn, Mary, Williams, Jeannie, Cabrales, Pedro, Abrouk, Nacer

Publikováno v: Frontiers in Immunology. 14

BackgroundBromonitrozidine (RRx-001) is a minimally toxic, NLRP3 inhibitor that has been observed, in experimental systems, to also downregulate CD47, repolarize tumor associated macrophages (TAMs) and normalize aberrant tumor perfusion. This phase 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cfdd466c29a1f8a4566361ef11405f
https://doi.org/10.3389/fimmu.2023.1104753

Anti-CD47 protilátka v nádorové terapii

Autor: LENCOVÁ, Radka

The aim of this thesis was to answer question whether it is possible to improve the effect of cancer immunotherapy. This is based on the combination of TLR agonists and the ligands stimulating phagocytosis. We used anti-CD47 antibody to block CD47 on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2186::534b14569a263e8696ceaa20837abd03
http://www.nusl.cz/ntk/nusl-382011

Human thrombospondin’s (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: A molecular modeling study

Autor: David Perahia, Stéphane Dedieu, Manuel Dauchez, Nicolas Floquet, Laurent Martiny

Publikováno v: Archives of Biochemistry and Biophysics
Archives of Biochemistry and Biophysics, Elsevier, 2008, 478 (1), pp.103-109. ⟨10.1016/j.abb.2008.07.015⟩

International audience; Thrombospondin-1 (TSP-1) interaction with the membranous receptor CD-47 involves the peptide RFYVVMWK (4N-1) located in its C-terminal domain. However, the available X-ray structure of TSP-1 describes this peptide as completel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814d4d719892fd1e1a9d28e3d9f155b0
https://doi.org/10.1016/j.abb.2008.07.015