A disease-associated gene desert orchestrates macrophage inflammatory responses via ETS2

Autor: CT Stankey, C Bourges, T Turner-Stokes, AP Piedade, C Palmer-Jones, I Papa, M Dos Silva dos Santos, LO Randzavola, L Speidel, EC Parkes, W Edwards, AP Rochford, CD Murray, JI MacRae, P Skoglund, C Wallace, MZ Cader, DC Thomas, JC Lee

Increasing global rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1and high failure rates during drug development2– underscoring an urgent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6b6133f81a729bebf8e7c96d026e458
https://doi.org/10.1101/2023.05.05.539522

PTH-044 A Single-centre Pilot Study Examining Internet Use For Health Related Information Among Patients With Inflammatory Bowel Disease

Autor: K Greveson, T Shepherd, M Hamilton, CD Murray

Publikováno v: Gut. 63:A228.1-A228

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e2b025fed7bdf194645961b593b2f6
https://doi.org/10.1136/gutjnl-2014-307263.490

P23 A Multidisciplinary Intervention to Reduce Antibiotic Duration in Lower Respiratory Tract Infections

Autor: James D. Chalmers, Stuart Schembri, Roland Smith, Thomas C. Fardon, CD Murray, Arlene Shaw

Publikováno v: Thorax. 67:A73.2-A74

Introduction Prolonged courses of antibiotics in patients with lower respiratory tract infections (LRTI) are common and may contribute to antibiotic related side effects and antibiotic resistance. Prescribing shorter antibiotic courses may be equally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24f54e8689e213ef13c9219aee1172eb
https://doi.org/10.1136/thoraxjnl-2012-202678.164

Systemic sclerosis-related fecal incontinence: a scoping review focusing on a neglected manifestation.

Autor: Lescoat A; Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France.; EHESP, Irset (Institut de Recherche en Santé, Univ Rennes, CHU Rennes, Inserm, Environnement et Travail) - UMR_S 1085., Zimmermann F; Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France.; EHESP, Irset (Institut de Recherche en Santé, Univ Rennes, CHU Rennes, Inserm, Environnement et Travail) - UMR_S 1085., Murray CD; Department of Gastroenterology, Royal Free London, London, UK., Khanna D; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.; Scleroderma Program, University of Michigan, Ann Arbor., Hughes M; Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, UK.; Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., McMahan ZH; Johns Hopkins University, Baltimore, Maryland.

Publikováno v: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Dec 18. Date of Electronic Publication: 2024 Dec 18.

A disease-associated gene desert directs macrophage inflammation through ETS2.

Autor: Stankey CT; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK.; Washington University School of Medicine, St Louis, MO, USA., Bourges C; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Haag LM; Division of Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Turner-Stokes T; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Piedade AP; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Palmer-Jones C; Department of Gastroenterology, Royal Free Hospital, London, UK.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK., Papa I; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Silva Dos Santos M; Metabolomics STP, The Francis Crick Institute, London, UK., Zhang Q; Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Hinxton, UK., Cameron AJ; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Legrini A; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Zhang T; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Wood CS; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., New FN; NanoString Technologies, Seattle, WA, USA., Randzavola LO; Department of Immunology and Inflammation, Imperial College London, London, UK., Speidel L; Ancient Genomics Laboratory, The Francis Crick Institute, London, UK.; Genetics Institute, University College London, London, UK., Brown AC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Hall A; The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK.; Department of Cellular Pathology, Royal Free Hospital, London, UK., Saffioti F; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK.; The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK., Parkes EC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK., Edwards W; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK., Direskeneli H; Department of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey., Grayson PC; Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, USA., Jiang L; Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China., Merkel PA; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Saruhan-Direskeneli G; Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey., Sawalha AH; Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Lupus Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Tombetti E; Department of Biomedical and Clinical Sciences, Milan University, Milan, Italy.; Internal Medicine and Rheumatology, ASST FBF-Sacco, Milan, Italy., Quaglia A; Department of Cellular Pathology, Royal Free Hospital, London, UK.; UCL Cancer Institute, London, UK., Thorburn D; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK.; The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK., Knight JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Chinese Academy of Medical Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Comprehensive Biomedical Research Centre, Oxford, UK., Rochford AP; Department of Gastroenterology, Royal Free Hospital, London, UK.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK., Murray CD; Department of Gastroenterology, Royal Free Hospital, London, UK.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK., Divakar P; NanoString Technologies, Seattle, WA, USA., Green M; Experimental Histopathology STP, The Francis Crick Institute, London, UK., Nye E; Experimental Histopathology STP, The Francis Crick Institute, London, UK., MacRae JI; Metabolomics STP, The Francis Crick Institute, London, UK., Jamieson NB; Wolfson Wohl Cancer Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK., Skoglund P; Ancient Genomics Laboratory, The Francis Crick Institute, London, UK., Cader MZ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Wallace C; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK., Thomas DC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Lee JC; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK. james.lee@crick.ac.uk.; Department of Gastroenterology, Royal Free Hospital, London, UK. james.lee@crick.ac.uk.; Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK. james.lee@crick.ac.uk.

Publikováno v: Nature [Nature] 2024 Jun; Vol. 630 (8016), pp. 447-456. Date of Electronic Publication: 2024 Jun 05.