Výsledky vyhledávání - "CD, Chow diet"

BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

Autor: Carlos Castaño, Gema Alcarraz-Vizán, Marcelina Párrizas, Sara de Pablo, Júlia Rodríguez-Comas, Joan-Marc Servitja, Mario Vallejo, Antonio Fernández-Pérez, Sara Ramírez, Daniela Díaz-Catalán, Anna Novials, Marc Claret

Publikováno v: Molecular Metabolism
Digital.CSIC. Repositorio Institucional del CSIC
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Molecular Metabolism, Vol 53, Iss, Pp 101251-(2021)

© 2021 The Author(s).
[Objective]: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7198fe332721e3e3ed6c3444b9e281b
http://europepmc.org/articles/PMC8190493

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Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

Autor: Randall L. Mynatt, Sheila R. Costford, Stephen J. Gardell, Bram Brouwers, David A. Sinclair, Lauren M. Sparks, Heather H. Cornnell, Julio E. Ayala, Hui Xie, Meghan E. Hopf, Fanchao Yi, Glenn A. Walter, Steven R. Smith, Timothy F. Osborne, Chris Petucci, Mauro Dispagna, Peter E. Phelan, Ana P. Gomes

Publikováno v: Molecular Metabolism, Vol 7, Iss, Pp 1-11 (2018)
Molecular Metabolism

Objective Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89a01374700cb489521f89013a4e5f9
https://doi.org/10.1016/j.molmet.2017.10.012

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Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function

Autor: Somasundaram Raghavan, Rima Chattopadhyay, Gadiparthi N. Rao

Publikováno v: Redox Biology, Vol 12, Iss, Pp 438-455 (2017)
Redox Biology

Resolvins are a novel class of lipid mediators that play an important role in the resolution of inflammation, although the underlying mechanisms are not very clear. To explore the anti-inflammatory mechanisms of resolvins, we have studied the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2456946e21afa8586484a8732cb972ef
http://www.sciencedirect.com/science/article/pii/S2213231717300642

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TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Autor: Michael D. Cameron, Qingzhang Zhu, Haifei Xu, James C. Barrow, Alice Asteian, Hua Lin, Baoji Xu, Sarbani Ghoshal, Theodore M. Kamenecka, Anutosh Chakraborty, Glen Ernst

Publikováno v: Molecular Metabolism, Vol 5, Iss 10, Pp 903-917 (2016)
Molecular Metabolism

Objective Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d11f5485a9473d413c3f70ce3dea24

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Adipose-specific BMP and activin membrane-bound inhibitor (BAMBI) deletion promotes adipogenesis by accelerating ROS production

Autor: Yanting Xu, Taiyong Yu, Gongshe Yang, Xiaoge Zhou, Xiaochang Chen, Kuilong Huang, Xiaoyu Wang, Chen Zhao, Weijun Pang, Yulong Wang

Publikováno v: The Journal of Biological Chemistry

With the improvement of people's living standards, the number of obese patients has also grown rapidly. It is reported that the level of oxidative stress in obese patients has significantly increased, mainly caused by the increase in reactive oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa01fa7d58c64d44260d6ff949f10acc
https://doi.org/10.1074/jbc.ra120.014793

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LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis

Autor: Liu Yang, Xunde Xian, Xiao Lin, Feng Wang, George Liu, Haibo Zhu, Kai Qu, Nathan Cong, Liqing Yu, Xin Guo, Jinjie Wang, Mingming Gao, Xiangbo An, Yunan Wang, Yuhui Wang

Publikováno v: EBioMedicine
EBioMedicine, Vol 27, Iss C, Pp 214-224 (2018)
EBioMedicine, Vol 28, Iss C, Pp 17-18 (2018)

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait. Hamsters, like humans, have the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9513d389b0666abb448ff5e49a748f48
https://pubmed.ncbi.nlm.nih.gov/29289533

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Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling

Autor: Jean-Marie Launay, Yves Rouillé, Patty Chen, Marc Foretz, Christophe Magnan, Ralf Jockers, Koichiro Ozawa, Stéphanie Migrenne, Jacques Mallet, Toru Hosoi, Clara Roujeau, Virginie Vauthier, Chamsy Sarkis, Julie Dam

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2017, 6 (1), pp.159-172. ⟨10.1016/j.molmet.2016.10.009⟩
Molecular metabolism, 2017, 6 (1), pp.159-172. ⟨10.1016/j.molmet.2016.10.009⟩
Molecular metabolism, Elsevier, 2017, 6 (1), pp.159-172. 〈10.1016/j.molmet.2016.10.009〉
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 1, Pp 159-172 (2017)

The hypothalamic arcuate nucleus (ARC) is a major integration center for energy and glucose homeostasis that responds to leptin. Resistance to leptin in the ARC is an important component of the development of obesity and type 2 diabetes. Recently, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3dd07a430881bcef302830b13ab301
https://hal.sorbonne-universite.fr/hal-01501632/file/1-s2.0-S2212877816302186-main.pdf

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Akademický článek

The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity.

Autor: Wang, Zhiwei¹ (AUTHOR), Yang, Shaying¹ (AUTHOR), Liu, Liangju¹ (AUTHOR), Mao, Aiqin¹ (AUTHOR), Kan, Hao¹ (AUTHOR), Yu, Fan¹ (AUTHOR), Ma, Xin^1,2 (AUTHOR), Feng, Lei¹ (AUTHOR) feng2008lei@163.com, Zhou, Tingting¹ (AUTHOR) tingtingchou@jiangnan.edu.cn

Publikováno v: Clinical & Translational Medicine. Dec2024, Vol. 14 Issue 12, p1-20. 20p.

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Akademický článek

Tat-Beclin-1 Peptide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Enhancing Hepatic Autophagy.

Autor: Chen, Chun-Liang¹ (AUTHOR) muzhikmuzhik@gmail.com, Huang, Fen-Fen² (AUTHOR) fl005@mail.aeust.edu.tw, Lin, Hsueh-Fang¹ (AUTHOR) d6169kimo@gmail.com, Wu, Chi-Chien³ (AUTHOR) kevin200074@gmail.com, Ni, Yen-Hsuan⁴ (AUTHOR) yhni@ntu.edu.tw, Lin, Yu-Cheng^1,2 (AUTHOR) drlinyucheng@ntu.edu.tw

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12372. 12p.

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Akademický článek

Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese mice.

Autor: Moon, Subin¹ (AUTHOR), Park, Yejin¹ (AUTHOR), Jang, Sooyeon¹ (AUTHOR), Kim, Saeha¹ (AUTHOR), Song, Dan-Gyeong¹ (AUTHOR), Shin, Dae-Chul¹ (AUTHOR), Lee, Chan Hee^1,2 (AUTHOR) chl22@hallym.ac.kr

Publikováno v: Journal of Neuroinflammation. 10/4/2024, Vol. 21 Issue 1, p1-17. 17p.

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