Zobrazeno 1 - 10
of 13
pro vyhledávání: '"CCh, carbachol"'
Autor:
Jennifer Foulke-Abel, Kelli F. Johnson, Mark Donowitz, Ruxian Lin, Nicholas C. Zachos, Sun Lee, Varsha Singh, Jianyi Yin, Huimin Yu, Yan Rong, Julie In
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 219-232 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9c60b3f44f4ec5b1ede8c2e9a502aa
https://doi.org/10.1016/j.jcmgh.2021.08.010
https://doi.org/10.1016/j.jcmgh.2021.08.010
Autor:
Sebastian Albinsson, Mario Grossi, Johan Holmberg, Catarina Rippe, Karl Swärd, Fatima Daoud, Azra Alajbegovic
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims YAP (Yap1) and TAZ (Wwtr1) are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and cancer pathogenesis. Genetic deletion of YAP/TAZ has shown their critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cb57df31ea17debc2f76426b849444
https://doi.org/10.1016/j.jcmgh.2020.09.014
https://doi.org/10.1016/j.jcmgh.2020.09.014
Autor:
Ahmed Emam Abdelnaby, Ryan E. Yoast, Jung Min Han, Natalia Lakomski, Vikas Arige, Scott M. Emrich, David I. Yule, James Sneyd, Geneviève Dupont, J. Cory Benson, Mohamed Trebak, Martin Johnson, Xuexin Zhang, Trayambak Pathak, Ping Xin, Nadine Hempel
Publikováno v:
The Journal of biological chemistry, 279 (4
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Mitochondrial Ca2+ uptake tailors the strength of stimulation of plasma membrane phospholipase C–coupled receptors to that of cellular bioenergetics. However, how Ca2+ uptake by the mitochondrial Ca2+ uniporter (MCU) shapes receptor-evoked interorg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203ae3650d01b502a62b4333bd567b31
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/333671
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/333671
Publikováno v:
The Journal of Biological Chemistry
Transient receptor potential canonical type 5 (TRPC5) ion channels are expressed in the brain and kidney and have been identified as promising therapeutic targets whose selective inhibition can protect against diseases driven by a leaky kidney filter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf825fab8dd647992a21e5c49767acc
http://europepmc.org/articles/PMC8191310
http://europepmc.org/articles/PMC8191310
Autor:
Evi Kostenis, Nicole Merten, Max Crüsemann, Julian Patt, Nina Heycke, Uli Rick, Eva Marie Pfeil, Gabriele M. König, Funda Eryilmaz, Stefan Kehraus, Jan H. Voss, Xavier Deupi, Christa E. Müller, Asuka Inoue, Judith Alenfelder
Publikováno v:
The Journal of Biological Chemistry
Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to implicate Gq/11 proteins in the regulation of diverse biological processes. An emergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad14382365f90e4057dbc24db130542
https://doi.org/10.1016/j.jbc.2021.100472
https://doi.org/10.1016/j.jbc.2021.100472
Autor:
Xiaopeng, Bai, Eikichi, Ihara, Katsuya, Hirano, Yoshimasa, Tanaka, Kayoko, Nakano, Satomi, Kita, Takahiro, Iwamoto, Haruei, Ogino, Mayumi, Hirano, Yoshinao, Oda, Kazuhiko, Nakamura, Yoshihiro, Ogawa
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Background and Aims Hydrogen sulfide (H2S) is a major physiologic gastrotransmitter. Its role in the regulation of the lower esophageal sphincter (LES) function remains unknown. The present study addresses this question. Methods Isometric contraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90e00b144e5b4405ac350842b3654d73
https://pubmed.ncbi.nlm.nih.gov/29379856
https://pubmed.ncbi.nlm.nih.gov/29379856
Autor:
Casey D. Stefanski, R. John MacLeod, Nancy M. Walker, Jinghua Liu, Lane L. Clarke, Ashlee M. Strubberg, Scott T. Magness
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 253-271 (2018)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Cystic fibrosis (CF) patients and CF mouse models have increased risk for gastrointestinal tumors. CF mice show augmented intestinal proliferation of unknown etiology and an altered intestinal environment. We examined the role of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60f9c5cd68403f7f6692e71d55e2957
https://doi.org/10.1101/156562
https://doi.org/10.1101/156562
Publikováno v:
Biochemical Journal
Direct phosphorylation of AC2 (adenylyl cyclase 2) by PKC (protein kinase C) affords an opportunity for AC2 to integrate signals from non-canonical pathways to produce the second messenger, cyclic AMP. The present study shows that stimulation of AC2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd11b40a8af35fdf66cda97c3392abb
https://doi.org/10.1042/bj20120279
https://doi.org/10.1042/bj20120279
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Akademický článek
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