Výsledky vyhledávání - "CCR5 inhibitors"

Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals

Autor: W.M.A. Niessen

Publikováno v: International Journal of Mass Spectrometry

Antiviral drugs are a class of compounds developed specifically for the treatment of viral infections. In the development and subsequent application of antiviral drugs, like for any other class of drugs, quantitative analysis in biological matrix is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb720d8b96d7574319f8d93675a3ad40
https://doi.org/10.1016/j.ijms.2020.116370

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Akademický článek

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Interaction of small molecule inhibitors of HIV-1 entry with CCR5

Autor: Stuart W. McCombie, Thomas P. Sakmar, Tatjana Dragic, Fotini Tsamis, Bahige M. Baroudy, Christoph Seibert, John W. Clader, John P. Moore, Anandan Palani, Svetlana Gavrilov, Shawn E. Kuhmann, Jayaram R. Tagat, Steven O. Smith, Weiwen Ying

Publikováno v: Virology. 349(1):41-54

The CC-chemokine receptor 5 (CCR5) is the major coreceptor for macrophage-tropic (R5) HIV-1 strains. Several small molecule inhibitors of CCR5 that block chemokine binding and HIV-1 entry are being evaluated as drug candidates. Here we define how CCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bf7b55794ac5ea33b739e547cfe2a9

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V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc

Autor: Rogier W. Sanders, Per Johan Klasse, Martin R. Jakobsen, Paul R Gorry, John P. Moore, Reem Berro

Publikováno v: Berro, R, Klasse, P J, Jakobsen, M R, Gorry, P R, Moore, J P & Sanders, R W 2012, ' V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc ', Virology, vol. 427, no. 2, pp. 158-65 . https://doi.org/10.1016/j.virol.2012.02.006
Virology, 427(2), 158-165. Academic Press Inc.
Virology

HIV-1 develops resistance to CCR5 antagonists such as Maraviroc (MVC) and Vicriviroc (VVC) both in vitro and in vivo, with most changes arising in the gp120 V3 region. Both compounds bind to the same hydrophobic cavity in CCR5 in subtly different way

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd525759086268b7d65d0595ef2bb164
https://europepmc.org/articles/PMC3320651/

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Kniha

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Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)

Autor: Tom Morgan, Carolina Herrera, Enid Rivera-Troche, Andre J. Marozsan, Bahige M. Baroudy, Shawn E. Kuhmann, John P. Moore, Serena Xu, Julie M. Strizki

Publikováno v: Virology. 338(1)

We describe the generation of two genetically related human immunodeficiency virus type 1 (HIV-1) isolates highly (>20,000-fold) resistant to the small molecule CCR5 inhibitor, SCH-417690 (formerly SCH-D). Both viruses were cross-resistant to other s

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https://pubmed.ncbi.nlm.nih.gov/15935415

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CCR5 inhibitors: Emerging promising HIV therapeutic strategy

Autor: Padmasri Kutikuppala Surya Rao

Publikováno v: Indian Journal of Sexually Transmitted Diseases

Though potent anti-HIV therapy has spectacularly reduced the morbidity and mortality of human immunodeficiency virus (HIV)-1 infection in the advanced countries, it continues to be associated with substantial toxicity, drug-drug interactions, difficu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177315c7e5b747944b5dcc58dd180db1
https://doi.org/10.4103/0253-7184.55471

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