V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc

Autor: Rogier W. Sanders, Per Johan Klasse, Martin R. Jakobsen, Paul R Gorry, John P. Moore, Reem Berro

Publikováno v: Berro, R, Klasse, P J, Jakobsen, M R, Gorry, P R, Moore, J P & Sanders, R W 2012, ' V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc ', Virology, vol. 427, no. 2, pp. 158-65 . https://doi.org/10.1016/j.virol.2012.02.006
Virology, 427(2), 158-165. Academic Press Inc.
Virology

HIV-1 develops resistance to CCR5 antagonists such as Maraviroc (MVC) and Vicriviroc (VVC) both in vitro and in vivo, with most changes arising in the gp120 V3 region. Both compounds bind to the same hydrophobic cavity in CCR5 in subtly different way

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd525759086268b7d65d0595ef2bb164
https://europepmc.org/articles/PMC3320651/