Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion

Autor: Klaudia Theresa Warzecha, Sebastian Huss, Ralf Weiskirchen, Tom Luedde, Matthias Bartneck, Marlene Kohlhepp, Christiane Koppe, Frank Tacke, Christian Trautwein, Viktor Fech

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology : CMGH 11(2), 327-347 (2020). doi:10.1016/j.jcmgh.2020.08.012

Background & aims Macrophages are key regulators of inflammation and cancer promotion in the liver, and their recruitment and activation is linked to chemokine receptor signaling. However, the exact roles of the chemokine receptors CCR2 and CCR5 for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9654bb906a6faeed56d8bb231bdb40f5
https://doi.org/10.1016/j.jcmgh.2020.08.012

Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics

Autor: Anna Shtro, Marina Dukhinova, Polina Kuchur, Elena Kokinos, Alexey Komissarov

Publikováno v: Cytokine & Growth Factor Reviews

Graphical abstract
Macrophages represent the first line of anti-pathogen defense - they encounter invading pathogens to perform the phagocytic activity, to deliver the plethora of pro- and anti-inflammatory cytokines, and to shape the tissue mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a702ed645dea7807089e0c4d5edaae
https://pubmed.ncbi.nlm.nih.gov/33342718

Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions

Autor: Haleh Davanian, Margaret Chen, Soo Aleman, Anthony T. Tan, Katie Healy, Antonio Bertoletti, Andrea Pavesi, Tiphaine Parrot, Johan K. Sandberg, Susanne E Reinsbach, Michał J. Sobkowiak

Publikováno v: JHEP Reports, Vol 3, Iss 4, Pp 100318-(2021)
JHEP Reports

Background & Aims Virus-specific T cell dysfunction is a common feature of HBV-related hepatocellular carcinoma (HBV-HCC). Conventional T (ConT) cells can be redirected towards viral antigens in HBV-HCC when they express an HBV-specific receptor; how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd0342307cbb74465ae0246e43031e6
https://doi.org/10.1016/j.jhepr.2021.100318

Understanding the mechanisms of viral induced asthma: New therapeutic directions

Autor: Jay C. Horvat, Philip M. Hansbro, Nicole G. Hansbro, Peter A. B. Wark

Publikováno v: Pharmacology & Therapeutics

Asthma is a common and debilitating disease that has substantially increased in prevalence in Western Societies in the last 2 decades. Respiratory tract infections by respiratory syncytial virus (RSV) and rhinovirus (RV) are widely implicated as comm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f954fdf5850eac1e885113fac7a5889
http://europepmc.org/articles/PMC7112677

Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

Autor: Yingmei Zhang, Rui Zhao, Yanan Liu, Qian-mei Xu, Wenling Han, Quansheng Song, Xue Yang, Chunhui Di, Dalong Ma, Ying Wang

Publikováno v: Life Sciences

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ed5718fd0d9959dffc598d0508ec96
http://europepmc.org/articles/PMC7126766