Zobrazeno 1 - 10
of 10
pro vyhledávání: '"CC50, 50% cytotoxic concentration"'
Autor:
David Shum, Seung Kew Yoon, Marc Peter Windisch, Soonju Park, Eva Zusinaite, Eunji Jo, Denis E. Kainov, Jaewon Yang, Pil Soo Sung, Alexander König
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 4, Pp 100296-(2021)
JHEP Reports, Vol 3, Iss 4, Pp 100296-(2021)
Background & Aims Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single experimental setup. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d39818aec9a96715b2a465ff2da762
https://hdl.handle.net/11250/3045132
https://hdl.handle.net/11250/3045132
Autor:
Hui Nan, Xiaodong Ren, Pengcheng Yu, Hong Liu, Qiao Guaiping, Wenqiang Cao, Liu Yuzhi, Ju Xingke, Li Han, Jia Minyi, Lei Tian, Li Juan, Liang Chengyuan
Publikováno v:
Phytomedicine Plus
Phytomedicine Plus, Vol 1, Iss 2, Pp 100027-(2021)
Phytomedicine Plus, Vol 1, Iss 2, Pp 100027-(2021)
Highlights • The present review summarizes the plausible molecular mechanism of specific LH capsules in the control of SARS-COV-2 infection and the inhibition of cytokine storms caused by IL-6. • Preclinical and clinical trials of LH capsules in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed6ee319ef2e397034c14aa22649908
https://doi.org/10.1016/j.phyplu.2021.100027
https://doi.org/10.1016/j.phyplu.2021.100027
Autor:
Ting-Ting Jong, Chih-Hsueh Yang, Wei-Li Hsu, Chi-Luan Wen, Shih-Lan Hsu, Poa-Chun Chang, Duen-Huey Tan
Publikováno v:
Journal of Ethnopharmacology
Ethnopharmacological relevance Peperomia sui Lin and Lu (Peperomia sui), a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. However, no previous study has explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b36c82d6a1c10344987fc2353e5fd5
https://doi.org/10.1016/j.jep.2014.05.035
https://doi.org/10.1016/j.jep.2014.05.035
Autor:
David A. Oare, I-hung Shih, Laura S. Lehman, Erik De Clercq, Eric Mabery, Steven S. Bondy, Weidong Zhong, Inge Vliegen, Matthew Paulson, Johan Neyts, Gerhard Pürstinger, Hans Reiser, Jan Paeshuyse, Nina Boddeker, Tine De Burghgraeve, William A. Lee
Publikováno v:
Journal of Hepatology
Background/Aims Following lead optimization, a set of substituted imidazopyridines was identified as potent and selective inhibitors of in vitro HCV replication. The particular characteristics of one of the most potent compounds in this series (5-[[3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034b0a9d32ab3e902fed4fe6a8554f20
http://europepmc.org/articles/PMC7114863
http://europepmc.org/articles/PMC7114863
Publikováno v:
Journal of Ethnopharmacology
Ethnopharmacological relevance Licorice (Glycyrrhiza uralensis Fisch., Leguminosae) has been used in herbal medicine and food supplement worldwide for centuries. Licorice is a common ingredient of several prescriptions of traditional Chinese medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0e18062b9edb67981c6697cfaa744d
https://pubmed.ncbi.nlm.nih.gov/23643542
https://pubmed.ncbi.nlm.nih.gov/23643542
Publikováno v:
Journal of Virological Methods
Journal of Virological Methods, Elsevier, 2009, 159 (2), pp.217-226. ⟨10.1016/j.jviromet.2009.03.023⟩
Journal of Virological Methods, Elsevier, 2009, 159 (2), pp.217-226. ⟨10.1016/j.jviromet.2009.03.023⟩
The relative lack of efficient methods for evaluating antiseptic antiviral activity, together with weaknesses in the existing European Standard (i.e. NF EN 14476+A1), underlines the need to seek a new method which could allow a more precise evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274899d5ad75b626228c60841e9294be
https://hal.univ-lorraine.fr/hal-01651214
https://hal.univ-lorraine.fr/hal-01651214
Autor:
Lang P; Sanofi, 153/211 Second Avenue, Waltham, MA, 02451, USA., Geertsen SS; Sanofi, 450 Water Street, Cambridge, MA, 02141, USA., Lublin AL; Sanofi, 450 Water Street, Cambridge, MA, 02141, USA., Potter MC; Sanofi, 450 Water Street, Cambridge, MA, 02141, USA., Gladysheva T; Sanofi, 153/211 Second Avenue, Waltham, MA, 02451, USA., Gregory JS; Sanofi, 153/211 Second Avenue, Waltham, MA, 02451, USA., Rufi P; Sanofi, 1 Av. Pierre Brossolette, 91380, Chilly-Mazarin, France.
Publikováno v:
Biochemistry and biophysics reports [Biochem Biophys Rep] 2023 Mar; Vol. 33, pp. 101395. Date of Electronic Publication: 2022 Nov 23.
Autor:
Liang C; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Hui N; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Liu Y; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Qiao G; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Li J; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Tian L; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Ju X; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Jia M; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Liu H; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai 519030, PR China., Cao W; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai 519030, PR China., Yu P; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China., Li H; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Ren X; Medical College, Guizhou University, Guiyang 550025, PR China.
Publikováno v:
Phytomedicine plus : international journal of phytotherapy and phytopharmacology [Phytomed Plus] 2021 May; Vol. 1 (2), pp. 100027. Date of Electronic Publication: 2021 Jan 16.
Autor:
Yang J; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea., König A; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea., Park S; Screening Discovery Platform, Institut Pasteur Korea, Seongnam-si, South Korea., Jo E; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea., Sung PS; Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.; Catholic University Liver Research Center, The Catholic University of Korea, Seoul, South Korea., Yoon SK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.; Catholic University Liver Research Center, The Catholic University of Korea, Seoul, South Korea., Zusinaite E; Institute of Technology, University of Tartu, Tartu, Estonia., Kainov D; Institute of Technology, University of Tartu, Tartu, Estonia.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Shum D; Screening Discovery Platform, Institut Pasteur Korea, Seongnam-si, South Korea., Windisch MP; Applied Molecular Virology Laboratory, Institut Pasteur Korea, Seongnam-si, South Korea.; Division of Bio-Medical Science and Technology, University of Science and Technology, Daejeon, South Korea.
Publikováno v:
JHEP reports : innovation in hepatology [JHEP Rep] 2021 Apr 30; Vol. 3 (4), pp. 100296. Date of Electronic Publication: 2021 Apr 30 (Print Publication: 2021).
Autor:
Luo Z; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., Kuang XP; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China.; Yunnan University of Traditional Chinese Medicine, Kunming 650550, China., Zhou QQ; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., Yan CY; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., Li W; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., Gong HB; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., Kurihara H; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., Li WX; Yunnan University of Traditional Chinese Medicine, Kunming 650550, China., Li YF; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China., He RR; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, College of Pharmacy, Jinan University, Guangzhou 612505, China.; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 612505, China.; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 612505, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Dec; Vol. 10 (12), pp. 2323-2338. Date of Electronic Publication: 2020 Jun 25.