CLINICAL AND MOLECULAR IMPACT OF RS3824662 POLYMORPHISM IN GATA3 IN THE DEVELOPMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA IN ADOLESCENTS AND YOUNG ADULTS

Autor: RLD Santos, TFD Amaral, MDV Lucas, CB Blunck, BA Lopes, M Emerenciano, TC Barbosa

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S357- (2024)

Introduction and objectives: The rs3824662 polymorphism in GATA3 is a risk variant for the development of B-cell precursor acute lymphoblastic leukemia (B-ALL), particularly BCR::ABL1-like ALL, a subtype of B-ALL defined by a gene expression profile

Externí odkaz: https://doaj.org/article/e62c9fa20cac4483bbb9100a8ee59c0d

RELATO DE CASO DE LEUCEMIA AGUDA NA INFÂNCIA COM SWITCH DE LINHAGEM

Autor: VM Rosa, ALR Pacheco, CIO Rego, BG Marques, EBC Miatelo, M Emerenciano, BA Lopes, CB Blunck, TC Barbosa, CL Ribeiro

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S636- (2024)

Objetivo: Relatar um caso de Leucemia Aguda que houve switch de linhagem na faixa etária pediátrica. Relato de caso: Paciente do sexo masculino de 14 anos de idade ao diagnóstico, previamente hígido,há três semanas da avaliação inicial aprese

Externí odkaz: https://doaj.org/article/acb58ce11dcd45689d837e7d2b5b5798

IDENTIFICAÇÃO DE MARCADORES CELULARES ASSOCIADOS COM IKZF1PLUS EM LEUCEMIA LINFOBLÁSTICA AGUDA DE CÉLULAS PRECURSORAS-B

Autor: CB Blunck, CP Poubel, BA Lopes, MB Mansur, M Emerenciano

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S157- (2021)

A leucemia linfoblástica aguda de células precursoras B (LLA-CPB) pode ser classificada pela ocorrência de várias alterações genéticas primárias. As alterações de número de cópias (CNAs) em genes relacionados ao desenvolvimento de célula

Externí odkaz: https://doaj.org/article/7f68fa5778f64b18a103ea094fdfc23d

Characterisation of cells markers associated with IKZF1 ^plus in BCP-ALL.

Autor: Blunck CB; Genetics of Acute Leukaemia Laboratory-GenLAb, Research and Innovation Coordination, Instituto Nacional de Câncer-INCA, Rua André Cavalcanti, 37, 6th floor, Rio de Janeiro, RJ 20231-050, Brazil., Poubel CP; Genetics of Acute Leukaemia Laboratory-GenLAb, Research and Innovation Coordination, Instituto Nacional de Câncer-INCA, Rua André Cavalcanti, 37, 6th floor, Rio de Janeiro, RJ 20231-050, Brazil., Lopes BA; Genetics of Acute Leukaemia Laboratory-GenLAb, Research and Innovation Coordination, Instituto Nacional de Câncer-INCA, Rua André Cavalcanti, 37, 6th floor, Rio de Janeiro, RJ 20231-050, Brazil., Barbosa TC; Genetics of Acute Leukaemia Laboratory-GenLAb, Research and Innovation Coordination, Instituto Nacional de Câncer-INCA, Rua André Cavalcanti, 37, 6th floor, Rio de Janeiro, RJ 20231-050, Brazil., Maciel ALT; Genetics of Acute Leukaemia Laboratory-GenLAb, Research and Innovation Coordination, Instituto Nacional de Câncer-INCA, Rua André Cavalcanti, 37, 6th floor, Rio de Janeiro, RJ 20231-050, Brazil., da Costa ES; Department of Paediatrics, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Figueiredo ADR; Onco-Haematology Section, Prontobaby Hospital da Criança Ltda, Rio de Janeiro, RJ, Brazil., Land MGP; Department of Paediatrics, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, Brazil., Schramm MT; Onco-Haematology Section, Prontobaby Hospital da Criança Ltda, Rio de Janeiro, RJ, Brazil; Haematology Unit, Hospital do Câncer I, Instituto Nacional de Câncer-INCA, Rio de Janeiro, RJ, Brazil., Ikoma-Coltutato MRV; Sabin Medicina Diagnóstica, Brasília, DF, Brazil., Gomes RG; Paediatric Oncology Unit, Instituto de Medicina Integral Prof Fernando Figueira, Recife, PE, Brazil., Lins MM; Paediatric Oncology Unit, Instituto de Medicina Integral Prof Fernando Figueira, Recife, PE, Brazil., Aguiar TF; Onco-Haematology Section, Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti, Rio de Janeiro, RJ, Brazil., Mansur MB; Biology of Childhood Leukaemia Team, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Emerenciano M; Genetics of Acute Leukaemia Laboratory-GenLAb, Research and Innovation Coordination, Instituto Nacional de Câncer-INCA, Rua André Cavalcanti, 37, 6th floor, Rio de Janeiro, RJ 20231-050, Brazil. Electronic address: memerenciano@inca.gov.br.

Publikováno v: Translational oncology [Transl Oncol] 2024 Dec; Vol. 50, pp. 102127. Date of Electronic Publication: 2024 Sep 22.

Outcome of adolescents and young adults with acute lymphoblastic leukemia in a single center in Brazil.

Autor: Aguiar TF; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil; Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti, Rio de Janeiro, RJ, Brazil., da Conceição Barbosa T; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil., Maciel ALT; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil., Blunck CB; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil., Sellos-Laclette J; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil., de Melo AC; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil., Mansur MB; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil; Children's Hospital, John Radcliffe Hospital, Oxford, UK; Weatherall Institute of Molecular Medicine -WIMM, University of Oxford, Oxford, UK., Emerenciano M; Instituto Nacional de Câncer (INCA), Rio de Janeiro, RJ, Brazil. Electronic address: memerenciano@inca.gov.br.

Publikováno v: Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2023 Jul; Vol. 45 Suppl 2, pp. S108-S112. Date of Electronic Publication: 2022 Aug 01.