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Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT1A and CB1 receptors

Autor: Ana Carolina Medeiros, R.B. Malvestio, Sabatino Maione, R.L. de Freitas, Sylmara Esther Negrini-Ferrari, Mariana Oliveira-Silva, L. Luongo, Norberto Cysne Coimbra, Patrícia Medeiros, Cláudia Maria Padovan

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that is putatively implicated in the chronic pain and depression. We investigated the activity of PrL cortex neurons in Wistar rats that underwent chronic cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bf8d42825240e4c6d3c03e2b1f59f8
https://doi.org/10.1016/j.brainresbull.2021.06.017

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Functional heterogeneity of POMC neurons relies on mTORC1 signaling

Autor: Nicolas, Saucisse, Wilfrid, Mazier, Vincent, Simon, Elke, Binder, Caterina, Catania, Luigi, Bellocchio, Roman A, Romanov, Stéphane, Léon, Isabelle, Matias, Philippe, Zizzari, Carmelo, Quarta, Astrid, Cannich, Kana, Meece, Delphine, Gonzales, Samantha, Clark, Julia M, Becker, Giles S H, Yeo, Xavier, Fioramonti, Florian T, Merkle, Sharon L, Wardlaw, Tibor, Harkany, Federico, Massa, Giovanni, Marsicano, Daniela, Cota

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 37 (2), pp.109800. ⟨10.1016/j.celrep.2021.109800⟩

International audience; Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0000360959c279d61ab7d2672628bc6
https://hal.inrae.fr/hal-03613014/document

Decreasing CB1 receptor signaling in Kupffer cells improves insulin sensitivity in obese mice

Autor: Jie Liu, George Kunos, Nathan J. Coffey, Yuefei Shen, Michael P. Czech, Bin Gao, Sarah M. Nicoloro, Resat Cinar, Grzegorz Godlewski, Zhou Zhou, Tony Jourdan, Myriam Aouadi

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2017, 6 (11), pp.1517-1528. 〈https://www.sciencedirect.com/science/article/pii/S2212877817305847?via%3Dihub〉. 〈10.1016/j.molmet.2017.08.011〉
Molecular metabolism, Elsevier, 2017, 6 (11), pp.1517-1528. ⟨10.1016/j.molmet.2017.08.011⟩
Molecular Metabolism, Vol 6, Iss 11, Pp 1517-1528 (2017)

International audience; Objective: Obesity-induced accumulation of ectopic fat in the liver is thought to contribute to the development of insulin resistance, and increased activity of hepatic CB1R has been shown to promote both processes. However, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d58f1630c5c98237683d8a6cb37bea
https://doi.org/10.1016/j.molmet.2017.08.011