Výsledky vyhledávání - "CATALYTIC NUCLEOPHILE"

On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology

Autor: Marthe T. C. Walvoort, Gijsbert A. van der Marel, Jeroen D. C. Codée, Herman S. Overkleeft

Publikováno v: Chemical Science, 4(3), 897-906. ROYAL SOC CHEMISTRY

The reactivity of sugar donors and the stability of covalent intermediates formed in both chemical and biological systems is an active subject of study in both glycochemistry and glycobiology. Knowledge of the structure of these intermediates is vita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f61bdbb137796e218802fc55afbc4e1
https://doi.org/10.1039/c2sc21610h

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Identification of a novel alpha-galatosidase from the hyperthermophilic archaeon Sulfolobus solfataricus

Autor: Phillip C. Wright, Willem M. de Vos, Stan J. J. Brouns, John van der Oost, Hao Wu, Nicole Smits, Ambrosius P. Snijders

Publikováno v: Journal of Bacteriology, 188(7), 2392-2399
Journal of Bacteriology 188 (2006) 7

Sulfolobus solfataricus is an aerobic crenarchaeon that thrives in acidic volcanic pools. In this study, we have purified and characterized a thermostable α-galactosidase from cell extracts of S. solfataricus P2 grown on the trisaccharide raffinose.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637aa025f8bc92d249e6bcfac86dfc25
https://doi.org/10.1128/jb.188.7.2392-2399.2006

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From covalent glycosidase inhibitors to activity-based glycosidase probes

Autor: Sybrin P. Schröder, Hermen S. Overkleeft, Gijsbert A. van der Marel, Johannes M. F. G. Aerts, Martin D. Witte, Lianne I. Willems, Jianbing Jiang, Jeroen D. C. Codée, Kah-Yee Li, Thomas J. N. Beenakker, Wouter W. Kallemeijn

Publikováno v: Chemistry, 20(35), 10864-10872. Wiley-VCH Verlag GmbH & Co. KGaA
Chemistry (Weinheim an der Bergstrasse, Germany), 20(35), 10864-10872. Wiley-VCH Verlag

Activity-based protein profiling has emerged as a powerful discovery tool in chemical biology and medicinal chemistry research. Success of activity-based protein profiling hinges on the presence of compounds that can covalently and irreversibly bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c73677b121a13251aa4e7658d17f393
https://research.rug.nl/en/publications/2d2c7db8-c759-41dd-a3d5-7fe1f5e4e725

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Identification of key amino acid residues inNeisseria polysacchareaamylosucrase

Autor: Birte Svensson, Pierre Monsan, Gabrielle Potocki de Montalk, René-Marc Willemot, Patricia Sarçabal, Magali Remaud-Simeon

Publikováno v: FEBS Letters
FEBS Letters, 2000, 474, pp.33-37
FEBS Letters, Wiley, 2000, 474, pp.33-37
Technical University of Denmark Orbit

Amylosucrase from Neisseria polysaccharea catalyzes the synthesis of an amylose-like polymer from sucrose. Sequence alignment revealed that it belongs to the glycoside hydrolase family 13. Site-directed mutagenesis enabled the identification of funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20be7a40176c33dca8456d08f264684e
https://doi.org/10.1016/s0014-5793(00)01567-2

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Replacement of the Catalytic Nucleophile Aspartyl Residue of Dextran Glucosidase by Cysteine Sulfinate Enhances Transglycosylation Activity

Autor: Wataru Saburi, Haruhide Mori, Momoko Kobayashi, Masayuki Okuyama, Atsuo Kimura

Dextran glucosidase from Streptococcus mutans (SmDG) catalyzes the hydrolysis of an α-1,6-glucosidic linkage at the nonreducing end of isomaltooligosaccharides and dextran. This enzyme has an Asp-194 catalytic nucleophile and two catalytically unrel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a458ce67deb8ae0e1751ce2bfc7edf9c
https://europepmc.org/articles/PMC3814762/

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A new archaeal beta-glycosidase from Sulfolobus solfataricus: Seeding a novel retaining beta-glycan-specific glycoside hydrolase family along with the human non-lysosomal glucosylceramidase GBA2

Autor: Cobucci-Ponzano B, Aurilia V, Gennaro Riccio, Henrissat B, Pm, Coutinho, Strazzulli A, Padula A, Mm, Corsaro, Pieretti G, Pocsfalvi G, Fiume I, Cannio R, Rossi M, Moracci M

Publikováno v: The Journal of biological chemistry
285 (2010): 20691–20703. doi:10.1074/jbc.M109.086470
info:cnr-pdr/source/autori:Cobucci-Ponzano B.; Aurilia V.; Riccio G.; Henrissat B.; Coutinho P.M.; Strazzulli A.; Padula A.; Corsaro M.M.; Pieretti G.; Pocsfalvi G.; Fiume I.; Cannio R.; Rossi M.; Moracci M./titolo:A new archaeal beta-glycosidase from Sulfolobus solfataricus: Seeding a novel retaining beta-glycan-specific glycoside hydrolase family along with the human non-lysosomal glucosylceramidase GBA2/doi:10.1074%2Fjbc.M109.086470/rivista:The Journal of biological chemistry (Print)/anno:2010/pagina_da:20691/pagina_a:20703/intervallo_pagine:20691–20703/volume:285
Europe PubMed Central

Carbohydrate active enzymes (CAZymes) are a large class of enzymes, which build and breakdown the complex carbohydrates of the cell. On the basis of their amino acid sequences they are classified in families and clans that show conserved catalytic me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::06dc79b66440c5cad2ffe3ae5bb1ee5d
http://www.cnr.it/prodotto/i/9069

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