Zobrazeno 1 - 10
of 76
pro vyhledávání: '"CARRIE E. MCCURDY"'
Autor:
Darian T. Carroll, Allie Miller, Jennifer Fuhr, Joseph M. Elsakr, Valerie Ricciardi, Alexa N. Del Bene, Stedman Stephens, Evan Krystofiak, Sarah R. Lindsley, Melissa Kirigiti, Diana L. Takahashi, Tyler A. Dean, Stephanie R. Wesolowski, Carrie E. McCurdy, Jacob E. Friedman, Kjersti M. Aagaard, Paul Kievit, Maureen Gannon
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionUsing a non-human primate (NHP) model of maternal Western-style diet (mWSD) feeding during pregnancy and lactation, we previously reported altered offspring beta:alpha cell ratio in vivo and insulin hyper-secretion ex vivo. Mitochondria a
Externí odkaz:
https://doaj.org/article/2aefe612d931437fb2599f63ef8e7bf0
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Taylor K. Soderborg, Rachel C. Janssen, Diana L. Takahashi, Tyler A. Dean, Oleg Varlamov, Jon D. Hennebold, Maureen Gannon, Kjersti M. Aagaard, Carrie E. McCurdy, Paul Kievit, Bryan C. Bergman, Kenneth L. Jones, Eric M. Pietras, Stephanie R. Wesolowski, Jacob E. Friedman
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112393- (2023)
Summary: Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to increasing prevalence of these diseases, yet mechanisms remain unclear. Here, using nonhum
Externí odkaz:
https://doaj.org/article/61f8abfb16c94221819b0fcca9d1aea3
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Rachel C. Janssen, Mark A. Lovell, Deborah A. Schady, Claire Levek, Kenneth L. Jones, Angelo D’Alessandro, Paul Kievit, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0014-e0014 (2023)
Pediatric NAFLD has distinct and variable pathology, yet causation remains unclear. We have shown that maternal Western-style diet (mWSD) compared with maternal chow diet (CD) consumption in nonhuman primates produces hepatic injury and steatosis in
Externí odkaz:
https://doaj.org/article/6bcad75da676422bbcbdb90a6e13d609
Autor:
Joseph M. Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A. Dean, Diana L. Takahashi, Elinor Sullivan, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul Kievit, Jacob E. Friedman, Kjersti M. Aagaard, Digna R. Velez Edwards, Maureen Gannon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a
Externí odkaz:
https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
Autor:
Kristoffer Svensson, Samuel A. LaBarge, Abha Sathe, Vitor F. Martins, Shahriar Tahvilian, Jennifer M. Cunliffe, Roman Sasik, Sushil K. Mahata, Gretchen A. Meyer, Andrew Philp, Larry L. David, Samuel R. Ward, Carrie E. McCurdy, Joseph E. Aslan, Simon Schenk
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 2, Pp 464-477 (2020)
Abstract Background Reversible ε‐amino acetylation of lysine residues regulates transcription as well as metabolic flux; however, roles for specific lysine acetyltransferases in skeletal muscle physiology and function are unknown. In this study, w
Externí odkaz:
https://doaj.org/article/19b284faa0d3446e92f314afabd7c769
Autor:
Michael J. Nash, Evgenia Dobrinskikh, Sean A. Newsom, Ilhem Messaoudi, Rachel C. Janssen, Kjersti M. Aagaard, Carrie E. McCurdy, Maureen Gannon, Paul Kievit, Jacob E. Friedman, Stephanie R. Wesolowski
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Maternal obesity affects nearly one-third of pregnancies and is a major risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescent offspring, yet the mechanisms behind NAFLD remain poorly understood. Here, we demonstrate that nonhuman pri
Externí odkaz:
https://doaj.org/article/74abddaa583647bc9452d4301229be48
Autor:
Eileen I. Chang, Byron Hetrick, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul J. Rozance, Laura D. Brown
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Intrauterine growth restricted (IUGR) fetuses are born with lower skeletal muscle mass, fewer proliferating myoblasts, and fewer myofibers compared to normally growing fetuses. Plasma concentrations of insulin, a myogenic growth factor, are lower in
Externí odkaz:
https://doaj.org/article/19521035d3f24affba43750c2b55aeb7
Autor:
Joseph M. Elsakr, Jennifer C. Dunn, Katherine Tennant, Sifang Kathy Zhao, Karly Kroeten, Raymond C. Pasek, Diana L. Takahashi, Tyler A. Dean, Digna R. Velez Edwards, Carrie E. McCurdy, Kjersti M. Aagaard, Alvin C. Powers, Jacob E. Friedman, Paul Kievit, Maureen Gannon
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 73-82 (2019)
Objective: In humans, offspring of women who are overweight or obese are more likely to develop metabolic disease later in life. Studies in lower animal species reveal that a calorically-dense maternal diet is associated with alterations in islet cel
Externí odkaz:
https://doaj.org/article/59c889a547274a3b82f1ccc31a532c7e
Autor:
Stephanie R. Wesolowski, Christopher M. Mulligan, Rachel C. Janssen, Peter R. Baker, II, Bryan C. Bergman, Angelo D'Alessandro, Travis Nemkov, Kenneth N. Maclean, Hua Jiang, Tyler A. Dean, Diana L. Takahashi, Paul Kievit, Carrie E. McCurdy, Kjersti M. Aagaard, Jacob E. Friedman
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 25-41 (2018)
Objective: Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dieta
Externí odkaz:
https://doaj.org/article/a28561519af14a2b8a154ec639481f85
Publikováno v:
Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-9 (2018)
Abstract Background Previous studies of lipoproteins in patients with sepsis have been performed on density fractions isolated by conventional ultracentrifugation that are heterogeneous and provide no information about the cargo of apoproteins presen
Externí odkaz:
https://doaj.org/article/cc52c8b1cdc7422da077c79b26e780ef