Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5

Autor: Jason G. Cyster, K. Mark Ansel, Caroline Low, Christopher D.C. Allen, Nobutaka Fujii, Robin Lesley, Hirokazu Tamamura

Publikováno v: Nature Immunology. 5:943-952

Germinal center (GC) dark and light zones segregate cells undergoing somatic hypermutation and antigen-driven selection, respectively, yet the factors guiding this organization are unknown. We report here that GC organization was absent from mice def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5cfefe6e4b9cdf5381808daa719476
https://doi.org/10.1038/ni1100

R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm

Autor: Gary Park, John McLaughlin, Vadim Markovtsov, Andrea Reitsma, Donald G. Payan, Shuling Fang, Chian Liu, Kazuya Shimoda, Elizabeth Tonkin, Haruko Shimoda, Jason Romero, Marina Gelman, Takuya Matsunaga, Allan Torneros, Rajinder Singh, Caroline Low, Wayne Lang, Jeffrey Clough, Polly Pine, Somasekhar Bhamidipati, Stacey Siu, Kotaro Shide, Matt Duan, Takuro Kameda, Yasumichi Hitoshi

Publikováno v: Blood. 117(25)

The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN pathogenesis. We developed R723, an orally bioavailable small molecule that inhibits JAK2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e81c7a5a4b17d3d8956edb535fef103
https://pubmed.ncbi.nlm.nih.gov/21531978

Linking non-peptide ligand binding mode to activity at the human cholecystokinin-2 receptor

Autor: Caroline Low, Daniel Fourmy, Barret Kalindjian, Magali Foucaud, Esther Marco, Chantal Escrieut

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (51), pp.35860-8. ⟨10.1074/jbc.M805513200⟩
Journal of Biological Chemistry, 2008, 283 (51), pp.35860-8. ⟨10.1074/jbc.M805513200⟩

International audience; Given the importance of G-protein-coupled receptors as pharmacological targets in medicine, efforts directed at the understanding the molecular mechanism by which pharmacological compounds regulate their activity is of paramou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d6f13e98dd9d2de1a1721b669a0c62
https://pubmed.ncbi.nlm.nih.gov/18936102

Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus

Autor: Matthew Forshaw, Caroline Lowrie, Derek Grose, Husam Marashi, Christina Wilson

Publikováno v: BMJ Open Gastroenterology, Vol 8, Iss 1 (2021)

Background Oesophageal cancer remains a common cause of cancer mortality worldwide. Increasingly, oncology centres are treating an older population and comorbidities may preclude multimodality treatment with chemoradiotherapy (CRT). We review outcome

Externí odkaz: https://doaj.org/article/51d6749b614a4e64a41c38496f2ba94e