Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine

Autor: Valérie Carraro, Lydie Combaret, Cécile Coudy-Gandilhon, Laurent Parry, Julien Averous, Anne-Catherine Maurin, Céline Jousse, Guillaume Voyard, Pierre Fafournoux, Isabelle Papet, Alain Bruhat

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (13), pp.7196. ⟨10.3390/ijms23137196⟩
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7196

Chronic treatment with acetaminophen (APAP) induces cysteine (Cys) and glutathione (GSH) deficiency which leads to adverse metabolic effects including muscle atrophy. Mammalian cells respond to essential amino acid deprivation through the phosphoryla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53806e9337882d8a142780795d6a13c1
https://hal.science/hal-03741978