Zobrazeno 1 - 10
of 11 365
pro vyhledávání: '"CARDIAC FIBROSIS"'
Autor:
Ting Fu, Muthukumar Mohan, Madhura Bose, Eoin P. Brennan, Helen Kiriazis, Minh Deo, Cameron J. Nowell, Catherine Godson, Mark E. Cooper, Peishen Zhao, Barbara K. Kemp-Harper, Owen L. Woodman, Rebecca H. Ritchie, Phillip Kantharidis, Cheng Xue Qin
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Diabetic heart disease may eventually lead to heart failure, a leading cause of mortality in diabetic individuals. The lack of effective treatments for diabetes-induced heart failure may result from a failure to address the underl
Externí odkaz:
https://doaj.org/article/fc19c4abf9f84f9897a35ef8502a37f2
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Cardiac fibrosis is common in myocardial infarction (MI), leading to progressive cardiac dysfunction. Studies suggested that the abnormal N 6-methyladenosine (m6A) modification induced by fat mass and obesity protein (FTO) is vita
Externí odkaz:
https://doaj.org/article/37484e16f55c4c0aa6ce1a65bfd93403
Autor:
Fumihiko Ogata, Shinsuke Hanatani, Naoya Nakashima, Masahiro Yamamoto, Yuichiro Shirahama, Masanobu Ishii, Noriaki Tabata, Hiroaki Kusaka, Kenshi Yamanaga, Hisanori Kanazawa, Tadashi Hoshiyama, Seiji Takashio, Hiroki Usuku, Yasushi Matsuzawa, Eiichiro Yamamoto, Hirofumi Soejima, Hiroaki Kawano, Hidetaka Hayashi, Seitaro Oda, Toshinori Hirai, Kenichi Tsujita
Publikováno v:
ESC Heart Failure, Vol 11, Iss 5, Pp 2924-2932 (2024)
Abstract Aims The human epididymis protein 4 (HE4), a novel fibrosis marker, is expressed only in activated fibroblasts and is thought to reflect ongoing left ventricular (LV) fibrosis. LV fibrosis is a feature of severe aortic stenosis (AS) and is r
Externí odkaz:
https://doaj.org/article/faa3d2140d6c48c4ad94884416de1ca6
Publikováno v:
Open Veterinary Journal, Vol 14, Iss 9, Pp 2287-2293 (2024)
Background: Cardiac fibrosis is often associated with various heart-related problems such as heart failure, atrial arrhythmia, and sudden cardiac death, making it a leading cause of death globally. Diabetes-associated fibrosis, on the other hand, is
Externí odkaz:
https://doaj.org/article/92abb3f0d24349fc9c078b9d11f67d1f
Autor:
Zhi-Yan Liu, Li-Chan Lin, Zhen-Yu Liu, Kai Song, Bin Tu, He Sun, Yang Zhou, Sui Mao, Ye Zhang, Rui Li, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Background N 6-methyladenosine (m6A) modification of messenger RNA (mRNA) is crucial for liquid-liquid phase separation in mammals. Increasing evidence indicates that liquid-liquid phase separation in proteins and RNAs affects diabetic cardi
Externí odkaz:
https://doaj.org/article/60f532a8b20542a6be55398296b0facd
Autor:
Baowei Zhang, Yizhang Wu, Chunjiang Zhou, Jiaxi Xie, Youming Zhang, Xingbo Yang, Jing Xiao, Dao Wu Wang, Congjia Shan, Xiujuan Zhou, Yaozu Xiang, Bing Yang
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Background Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized with progressive cardiac fibrosis and heart failure. However, the exact mechanism driving the progression of cardiac fibrosis and heart failure in AC
Externí odkaz:
https://doaj.org/article/d7914032d6aa4b56bc12cd2bfab1e3a7
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 7, Pp 832-840 (2024)
Objective(s): Slit guidance ligand 3 (SLIT3) has been identified as a potential therapeutic regulator against fibroblast activity and fibrillary collagen production in an autocrine manner. However, this research aims to investigate the potential role
Externí odkaz:
https://doaj.org/article/532d63f25b054662b67196e1964d033d
Autor:
Yan Han, Zehua Shao, Yuanhao Zhang, Huan Zhao, Zirui Sun, Chaokuan Yang, Hao Tang, Yu Han, Chuanyu Gao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract This study investigates how dynamic fluctuations in matrix stiffness affect the behavior of cardiac fibroblasts (CFs) within a three-dimensional (3D) hydrogel environment. Using hybrid hydrogels with tunable stiffness, we created an in vitro
Externí odkaz:
https://doaj.org/article/cfca4ea9b61a44578d109b58e84df563
Publikováno v:
International Journal of General Medicine, Vol Volume 17, Pp 3147-3169 (2024)
Man Yang,1– 3,* Xiang Xu,4,5,* Xing-an Zhao,1,2 Yun-na Ge,1,2 Juan Qin,1 Xi-ya Wang,1,2 Hua-lei Dai,1 Ji Jia,1 Si-ming Tao1 1Department of Cardiology, The Affiliated Hospital of Yunnan University, Kunming City, Yunnan Province, People’s R
Externí odkaz:
https://doaj.org/article/297e95b3432f4093b685c626dff099b0
Publikováno v:
FEBS Open Bio, Vol 14, Iss 7, Pp 1101-1115 (2024)
Heart failure with preserved ejection fraction (HFpEF) is one of the major subtypes of heart failure (HF) and no effective treatments for this common disease exist to date. Cardiac fibrosis is central to the pathology of HF and a potential avenue for
Externí odkaz:
https://doaj.org/article/bbf677dfa1574e7ea652cbb947b7c01c