Zobrazeno 1 - 10
of 17
pro vyhledávání: '"CARD, caspase activation and recruitment domain"'
Publikováno v:
Seminars in Cell & Developmental Biology
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628bb448c2d6de5b9d7755cdadd35794
http://europepmc.org/articles/PMC7448748
http://europepmc.org/articles/PMC7448748
Autor:
Lisardo Boscá, Carmen Delgado, Rafael I. Jaén, Almudena Val-Blasco, María Fernández-Velasco, Jose Lopez-Sendon, Marta Gil-Fernández, Patricia Prieto, Tarik Smani
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
JACC: Basic to Translational Science
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
instname
JACC: Basic to Translational Science
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Central Illustration
Highlights • The present review recapitulates relevant findings related to the role of the receptors of the innate immune system (TLRs and NLRs) in the progression of the most prevalent CVDs. • TLRs and NLRs play a key r
Highlights • The present review recapitulates relevant findings related to the role of the receptors of the innate immune system (TLRs and NLRs) in the progression of the most prevalent CVDs. • TLRs and NLRs play a key r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1d6d393016f9f807d1f1f67e4a58c1
http://hdl.handle.net/10261/222223
http://hdl.handle.net/10261/222223
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infection
Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddc4d9d42601f3845bf94ae189aa4cb
https://doi.org/10.1016/j.bcp.2018.08.044
https://doi.org/10.1016/j.bcp.2018.08.044
Autor:
Balabhaskararao Kancharana, Thirumala-Devi Kanneganti, Min Zheng, Rajendra Karki, Hartmut Berns, Shondra M. Pruett-Miller
Publikováno v:
The Journal of Biological Chemistry
The innate immune system acts as the first line of defense against infection. One key component of the innate immune response to gram-negative bacterial infections is inflammasome activation. The caspase-11 (CASP11)-nucleotide-binding oligomerization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49338282eee099a504adf2c33da8f5bc
https://doi.org/10.1016/j.jbc.2021.101379
https://doi.org/10.1016/j.jbc.2021.101379
Autor:
Sjors H.W. Scheres, Shaoda He
Publikováno v:
Journal of Structural Biology
We describe a new implementation for the reconstruction of helical assemblies in the empirical Bayesian framework of RELION. Our approach calculates optimal linear filters for the 3D reconstruction by embedding helical symmetry operators in Fourier-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500437f18e9d49a29a9887fb978880e1
https://doi.org/10.1016/j.jsb.2017.02.003
https://doi.org/10.1016/j.jsb.2017.02.003
Autor:
Ferrand, Audrey, Al Nabhani, Ziad, Sola Tapias, Nùria, Mas, Emmanuel, Hugot, Jean-Pierre, Barreau, Frederick
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology 2 (7), 357-369. (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2019, 7 (2), pp.357-369. ⟨10.1016/j.jcmgh.2018.10.009⟩
Cellular and Molecular Gastroenterology and Hepatology, 2019, 7 (2), pp.357-369. ⟨10.1016/j.jcmgh.2018.10.009⟩
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2019, 7 (2), pp.357-369. ⟨10.1016/j.jcmgh.2018.10.009⟩
Cellular and Molecular Gastroenterology and Hepatology, 2019, 7 (2), pp.357-369. ⟨10.1016/j.jcmgh.2018.10.009⟩
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3266afef71f38ab8c3f38cc56fe909b6
http://prodinra.inra.fr/record/464883
http://prodinra.inra.fr/record/464883
Publikováno v:
Biochimica et Biophysica Acta. Molecular Cell Research
RNA viruses have rapidly evolving genomes which often allow cross-species transmission and frequently generate new virus variants with altered pathogenic properties. Therefore infections by RNA viruses are a major threat to human health. The infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e433c7bf9c1b912e0fd5eb8df0e6ea9a
https://doi.org/10.1016/j.bbamcr.2014.08.004
https://doi.org/10.1016/j.bbamcr.2014.08.004
Publikováno v:
Cytokine & Growth Factor Reviews
During the immune response, striking the right balance between positive and negative regulation is critical to effectively mount an anti-microbial defense while preventing detrimental effects from exacerbated immune activation. Intra-cellular immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8510a75bcc7b791963c2adea3f1939
http://europepmc.org/articles/PMC7173094
http://europepmc.org/articles/PMC7173094
Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface
Autor:
Heike Schützle, Reinhard Berner, Kai Lehmberg, Dominic De Nardo, Sebastian Brenner, Sigrun R. Hofmann, Huasong Zeng, Bingtai Lu, Stefan Winkler, Fiona Moghaddas, Ping Zeng, Li Zhang, Ian P. Wicks, Suyun Cheng, Yuanbo Zhao, Yuxia Zhang, Peter E. Czabotar, Christian M. Hedrich, Xiaoyun Chen, Scott W. Canna, Seth L. Masters
Publikováno v:
The Journal of Allergy and Clinical Immunology
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Background Monogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example by gain-of-function mutations in inflammasome-forming proteins, such as NOD-like receptor family CARD-containing 4 protein (NL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad165840ed2fb55e58c2a4159f1c7f7
http://europepmc.org/articles/PMC6281029
http://europepmc.org/articles/PMC6281029
Autor:
Rhiannon, Parkhouse, Joseph P, Boyle, Sophie, Mayle, Kovilen, Sawmynaden, Katrin, Rittinger, Tom P, Monie
Publikováno v:
Febs Letters
Highlights • We have studied the interaction between NOD2 and CARD9. • The NACHT domain and CARD–NACHT linker of NOD2 are crucial for the interaction. • The CARD domains of NOD2 and CARD9 do not directly interact.
NOD2 activation by mura
NOD2 activation by mura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51973eb269394d77590c6c2ac16be2af
https://pubmed.ncbi.nlm.nih.gov/24960071
https://pubmed.ncbi.nlm.nih.gov/24960071