Zobrazeno 1 - 10
of 1 082
pro vyhledávání: '"CARBOHYDRATE ANTIGENS"'
Autor:
Francesca Rosato, Rajeev Pasupuleti, Jana Tomisch, Ana Valeria Meléndez, Dajana Kolanovic, Olga N. Makshakova, Birgit Wiltschi, Winfried Römer
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-26 (2022)
Abstract Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and r
Externí odkaz:
https://doaj.org/article/585c28734c1647a7bb3fc5ca436b7ed3
Akademický článek
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Publikováno v:
Molecules, Vol 28, Iss 20, p 7112 (2023)
Glycans on the surface of bacteria have diverse and essential biological functions and have widely been employed for treating various bacterial infectious diseases. Furthermore, these glycans comprise various functional groups, such as O-, N-, and ca
Externí odkaz:
https://doaj.org/article/6d041391099142e887f711a931f46ccf
A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells
Autor:
Jana Tomisch, Vincent Busse, Francesca Rosato, Olga N. Makshakova, Pavel Salavei, Anna-Sophia Kittel, Emilie Gillon, Levin Lataster, Anne Imberty, Ana Valeria Meléndez, Winfried Römer
Publikováno v:
Cells, Vol 12, Iss 14, p 1896 (2023)
Aberrant glycosylation plays a crucial role in tumour progression and invasiveness. Tumour-associated carbohydrate antigens (TACAs) represent a valuable set of targets for immunotherapeutic approaches. The poor immunogenicity of glycan structures, ho
Externí odkaz:
https://doaj.org/article/290edc1f0eca4de8b68170df837ec1bc
Publikováno v:
Translational Oncology, Vol 18, Iss , Pp 101348- (2022)
The membrane-bound MUC1 mucin is overexpressed and aberrantly glycosylated in many epithelium origin cancers. One of the promising strategies in cancer therapy is combining monoclonal antibodies against cancer related antigens, like MUC1, with chemot
Externí odkaz:
https://doaj.org/article/9517b4d4367a4c07b3870fd51e706c5d
Autor:
Joseph J. Barchi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design. Recent advances in immunotherapy as a treatment for a variety of
Externí odkaz:
https://doaj.org/article/99294ae08cfc4880a0d90d14b2090e06
Publikováno v:
Molecules, Vol 28, Iss 4, p 1934 (2023)
KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance,
Externí odkaz:
https://doaj.org/article/0961555f22a5488fa9ff6924ee74a47f
Akademický článek
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Publikováno v:
Reproductive and Developmental Medicine, Vol 2, Iss 1, Pp 46-51 (2018)
Background: Chronic inflammation has been reported as a triggering and driving factor in the pathogenesis of various diseases and is believed to be closely associated with tumor pathogenesis. In this study, we aimed to explore the changes of the infl
Externí odkaz:
https://doaj.org/article/fa46fdb7b1544bb99483a1651b24b528