Zobrazeno 1 - 10
of 104
pro vyhledávání: '"CAR-M"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Chimeric Antigen Receptor (CAR) technology has revolutionized cellular immunotherapy, particularly with the success of CAR-T cells in treating hematologic malignancies. However, CAR-T cells have the limited efficacy of against solid tumors. To addres
Externí odkaz:
https://doaj.org/article/1e1f7d4040424f05b4a1723e935b3f0f
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancers during the previous ten years. However, its effectiveness in treating solid tumors is still lacking, necessitating th
Externí odkaz:
https://doaj.org/article/58704e18d07644a5b9e8abf9d6757e73
Autor:
Lili Guan, Shanshan Wu, Qinyao Zhu, Xiaofang He, Xuelong Li, Guangqi Song, Luo Zhang, Xiushan Yin
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101741- (2024)
Chimeric antigen receptor (CAR)-modified macrophages are a promising treatment for solid tumor. So far the potential effects of CAR-M cell therapy have rarely been investigated in hepatocellular carcinoma (HCC). Glypican-3 (GPC3) is a biomarker for a
Externí odkaz:
https://doaj.org/article/67c9f07ed25d48ad97605b63b30442fd
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Surgery, chemotherapy, and endocrine therapy have improved the overall survival and postoperative recurrence rates of Luminal A, Luminal B, and HER2-positive breast cancers but treatment modalities for triple-negative breast cancer (TNBC) with poor p
Externí odkaz:
https://doaj.org/article/8f4613ddac7f4570b2b2f807a094a2ab
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Head and neck squamous cell carcinoma (HNSCC) rank among the most prevalent types of head and neck cancer globally. Unfortunately, a significant number of patients receive their diagnoses at advanced stages, limiting the effectiveness of available tr
Externí odkaz:
https://doaj.org/article/2fc8e8ff3d624f7e9310b07e308ef4f5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
In Mantle Cell Lymphoma (MCL), the role of macrophages within the tumour microenvironment (TME) has recently gained attention due to their impact on prognosis and response to therapy. Despite their low absolute number in MCL tumour tissue, recent fin
Externí odkaz:
https://doaj.org/article/3a7278a0a0e7476d87eafe1a29abce44
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The global increase in cancer incidence presents significant economic and societal challenges. While chimeric antigen receptor-modified T cell (CAR-T) therapy has demonstrated remarkable success in hematologic malignancies and has earned FDA approval
Externí odkaz:
https://doaj.org/article/6023c8cf341f4979ac7e5cf3d2be445c
Autor:
Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang, Tao Wang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M therapy has shown unique and impressive antitumor effects in immunotherapy
Externí odkaz:
https://doaj.org/article/c7d138c448504d7eb2f0d255c213db3c
Autor:
Karama Makni Maalej, Maysaloun Merhi, Varghese P. Inchakalody, Sarra Mestiri, Majid Alam, Cristina Maccalli, Honar Cherif, Shahab Uddin, Martin Steinhoff, Francesco M. Marincola, Said Dermime
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-54 (2023)
Abstract In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach to fight cancers. This approach consists of genetically engineered immune cells expressing a surface receptor, called CA
Externí odkaz:
https://doaj.org/article/7971c1c1f7b74ee4a963643e95c66a43
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-28 (2022)
Abstract In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most abundant immune cells, which act as a key regulator in tumorigenesis and progression. Increasing evidence have demonstrated that the TME alters the nature
Externí odkaz:
https://doaj.org/article/6fe9cdf45eb04d93ab4724c45e0eefb6