Zobrazeno 1 - 10
of 6 485
pro vyhledávání: '"CAR T-cell"'
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract In recent years, immunotherapy has developed rapidly as a new field of tumour therapy. However, the efficacy of tumour immunotherapy is not satisfactory due to the immune evasion mechanism of tumour cells, induction of immunosuppressive tumo
Externí odkaz:
https://doaj.org/article/c59c35806000402bb07f80262594176d
Autor:
Xiaoxi Zhou, Qiuxia Yu, Zigang Dai, Jue Wang, Chunrui Li, Liang Huang, Yicheng Zhang, Yang Cao
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-6 (2024)
Abstract Relapsed/refractory (R/R) primary and secondary central nervous system lymphomas (PCNSL, SCNSL) are associated with short survival and represent an unmet need, requiring novel effective strategies. We retrospectively compared the safety and
Externí odkaz:
https://doaj.org/article/07e8dc0d486f4f0ebba53ec5ac6f86fd
Autor:
Xianjun Li, Tianjun Chen, Xuehan Li, Hanyu Zhang, Yingjing Li, Shuyuan Zhang, Shengnan Luo, Tongsen Zheng
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Chimeric antigen receptor (CAR) T cell therapy, which targets tumors with high specificity through the recognition of particular antigens, has emerged as one of the most rapidly advancing modalities in immunotherapy, demonstrating substantia
Externí odkaz:
https://doaj.org/article/856a1647235f462793d6ed0e80614606
Autor:
Fatemeh Nasiri, Yasaman Asaadi, Farzaneh Mirzadeh, Shahrokh Abdolahi, Sedigheh Molaei, Somayeh Piri Gavgani, Fatemeh Rahbarizadeh
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-31 (2024)
Abstract Multiple myeloma (MM) is a hematological cancer characterized by the abnormal proliferation of plasma cells. Initial treatments often include immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal antibodies (mAbs). Desp
Externí odkaz:
https://doaj.org/article/6b0a7e5a21414a61a1cddb7dba91e414
Autor:
Ling-Shuang Sheng, Rong Shen, Zi-Xun Yan, Chao Wang, Xin Zheng, Yi-Lun Zhang, Hao-Xu Yang, Wen Wu, Peng-Peng Xu, Shu Cheng, Emmanuel Bachy, Pierre Sesques, Nicolas Jacquet-Francillon, Xu-Feng Jiang, Wei-Li Zhao, Li Wang
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-7 (2024)
Abstract Chimeric antigen receptor T (CAR-T) cell therapy has greatly improved the prognosis of relapsed and refractory patients with large B-cell lymphoma (LBCL). Early identification and intervention of patients who may respond poorly to CAR-T cell
Externí odkaz:
https://doaj.org/article/4b9725d563dd402392bbdf87337f7ad2
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-11 (2024)
Abstract Follicular lymphoma (FL) is an indolent, germinal center B cell–derived lymphoid neoplasm, for which recent advances in treatment have substantially improved patient survival. However, FL remains an incurable and heterogeneous disease, wit
Externí odkaz:
https://doaj.org/article/85a2892529414ce1aa105915033a0f01
Autor:
Saba Maleki, Zahra Esmaeili, Niloofar Seighali, Arman Shafiee, Sara Montazeri Namin, Mohammad Amin Tofighi Zavareh, Sima Shamshiri Khamene, Izat Mohammadkhawajah, Michael Nanna, Azin Alizadeh-asl, Jennifer M.Kwan, Kaveh Hosseini
Publikováno v:
Cardio-Oncology, Vol 10, Iss 1, Pp 1-21 (2024)
Abstract Purpose Chimeric antigen receptor (CAR) T-cell therapy is a new revolutionary method for treating refractory or relapsed hematologic malignancies, CAR T-cell therapy has been associated with cytokine release syndrome (CRS) and cardiotoxicity
Externí odkaz:
https://doaj.org/article/a4c063feb7c54dc295c6e1974c2a37cf
Publikováno v:
hLife, Vol 2, Iss 8, Pp 380-396 (2024)
Chimeric antigen receptor (CAR)-T cell therapy has made remarkable breakthroughs in treating cancers, especially hematologic malignancies, yet its broader application in cancer treatment is hindered by multiple challenges. Meanwhile, the development
Externí odkaz:
https://doaj.org/article/ed76607c896a4bdf9563cffeebd80d5e
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-5 (2024)
Abstract Chimeric antigen receptor (CAR) serves as the foundational element of CAR-T cells. Exogenous CAR molecules can exert functional effects on allogeneic T cells, leading to their activation and subsequent functional alterations. Here we show a
Externí odkaz:
https://doaj.org/article/e1e4c348ba4747daa4d3c2b51d5a742e
Autor:
Deepak Chandra Joshi, Anurag Sharma, Sonima Prasad, Karishma Singh, Mayank Kumar, Kajal Sherawat, Hardeep Singh Tuli, Madhu Gupta
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-40 (2024)
Abstract Novel therapeutic agents in clinical trials offer a paradigm shift in the approach to battling this prevalent and destructive disease, and the area of cancer therapy is on the precipice of a trans formative revolution. Despite the importance
Externí odkaz:
https://doaj.org/article/1794742c1bfd4630b3d8325ec0c1be5a