A syngle cycle of treatment with temozolomide, alone or combined with O6-benzylguanine, induces strong chemoresistance in melanoma cell clones: role of o6-methylguanine-DNA methyltransferase and the mismatch repair system

Autor: ALVINO E(1), CASTIGLIA D(2), CAPORALI E(3), PEPPONI R(3, CAPORASO P(3), LACAL PM(3), MARRA G(4), FISCHER F(4), ZAMBRUNO G(2), BONMASSAR E(5), JIRICNY J(4), D'ATRI S(3).

Publikováno v: International journal of oncology 29 (2006): 785–797.
info:cnr-pdr/source/autori:ALVINO E(1),CASTIGLIA D(2), CAPORALI E(3), PEPPONI R(3,6), CAPORASO P(3), LACAL PM(3), MARRA G(4), FISCHER F(4), ZAMBRUNO G(2), BONMASSAR E(5), JIRICNY J(4), D'ATRI S(3)./titolo:A syngle cycle of treatment with temozolomide, alone or combined with O6-benzylguanine, induces strong chemoresistance in melanoma cell clones: role of o6-methylguanine-DNA methyltransferase and the mismatch repair system./doi:/rivista:International journal of oncology/anno:2006/pagina_da:785/pagina_a:797/intervallo_pagine:785–797/volume:29

Clinically achievable concentrations of temozolomide (TMZ) produce cytotoxic effects only in mismatch repair (MMR)-proficient cells endowed with low O6-methylguanine-DNA methyltransferase (MGMT) activity. Aim of the present study was to investigate t

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http://www.cnr.it/prodotto/i/4697