Zobrazeno 1 - 10
of 22
pro vyhledávání: '"CANDACE M. RENO"'
Publikováno v:
Physiological Reports, Vol 12, Iss 16, Pp n/a-n/a (2024)
Abstract Hypoglycemia is common in people with type 1 diabetes. Sometimes, severe hypoglycemia can be fatal. The underlying mechanisms by which severe hypoglycemia can lead to death are unclear. The sympathetic nervous system is thought to be proarrh
Externí odkaz:
https://doaj.org/article/59792270fd394b05abd32abe076be197
Publikováno v:
Metabolites, Vol 13, Iss 10, p 1089 (2023)
Hypoglycemia occurs frequently in people with type 1 and type 2 diabetes. Hypoglycemia activates the counter-regulatory response. Besides peripheral glucose sensors located in the pancreas, mouth, gastrointestinal tract, portal vein, and carotid body
Externí odkaz:
https://doaj.org/article/3ded7601e68d41ab8ce213fca75750f8
Autor:
Candace M. Reno-Bernstein, Milan Oxspring, Justin Bayles, Emily Yiqing Huang, Ivana Holiday, Simon J. Fisher
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 323:E428-E434
In people with type 1 diabetes, hypoglycemia can induce cardiac arrhythmias. In rodent experiments, severe hypoglycemia can induce fatal cardiac arrhythmias, especially so in diabetic models. Increased oxidative stress associated with insulin-deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0b3a609fe6a00737b09efa5efae266
https://doi.org/10.1152/ajpendo.00188.2022
https://doi.org/10.1152/ajpendo.00188.2022
Publikováno v:
Diabetes. 71
Several clinical trials have noted an association between hypoglycemia and major cardiovascular events; however, a direct link between antecedent hypoglycemia and worse cardiac outcomes has not been established. We hypothesized that antecedent recurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a460fca3996e0ea0e7dae179d0a1b7
https://doi.org/10.2337/db22-231-or
https://doi.org/10.2337/db22-231-or
Autor:
Sejal Mistry, Ramkiran Gouripeddi, Candace M. Reno, Samir Abdelrahman, Simon J. Fisher, Julio C. Facelli
Publikováno v:
PLOS ONE. 18:e0284622
Sudden death related to hypoglycemia is thought to be due to cardiac arrhythmias. A clearer understanding of the cardiac changes associated with hypoglycemia is needed to reduce mortality. The objective of this work was to identify distinct patterns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84df812f27c2a627b0d2af0bff7de555
https://doi.org/10.1371/journal.pone.0284622
https://doi.org/10.1371/journal.pone.0284622
Publikováno v:
Diabetes. 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac0f46935eb7d92bd7767e616ecf41e
https://doi.org/10.2337/db21-44-or
https://doi.org/10.2337/db21-44-or
Autor:
Rahul Agrawal, Yiqing Huang, Sunny Sharma, Camille G. Christensen, Candace M. Reno, Simon J. Fisher
Publikováno v:
Am J Physiol Endocrinol Metab
The brain has traditionally thought to be insensitive to insulin, primarily because insulin does not stimulate glucose uptake/metabolism in the brain (as it does in classic insulin sensitive tissues such as muscle, liver and fat). However, over the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629b4b73ff75e42da12525e98cf105e9
https://europepmc.org/articles/PMC8321819/
https://europepmc.org/articles/PMC8321819/
Autor:
Yiqing Huang, Justin Bayles, Simon J. Fisher, Camille G. Christensen, Milan B. Oxspring, Candace M. Reno
Publikováno v:
Diabetes. 69
It was hypothesized that in response to insulin-induced severe hypoglycemia, excess calcium influx into the heart causes fatal cardiac arrhythmias. To test if blocking the calcium channels would decrease fatal cardiac arrhythmias during severe hypogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e311b43f1a50774859ebec4891fc87a
https://doi.org/10.2337/db20-158-or
https://doi.org/10.2337/db20-158-or
Autor:
Yiqing Huang, Milan B. Oxspring, Simon J. Fisher, Ivana Holiday, Justin Bayles, Candace M. Reno
Publikováno v:
Diabetes. 69
Severe hypoglycemia can lead to fatal cardiac arrhythmias. Our studies have shown that diabetes, per se, increases the risk of hypoglycemia-induced mortality in rats. It was hypothesized that excess oxidative stress, associated with diabetes, increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39598a830b609ea68f9ddaa7cd025ee
https://doi.org/10.2337/db20-159-or
https://doi.org/10.2337/db20-159-or
Publikováno v:
Endocrinology. 159:2614-2620
Sulfonylureas increase the incidence of severe hypoglycemia in people with type 2 diabetes and might increase the risk of sudden cardiac death. Sulfonylureas stimulate insulin secretion by closing pancreatic ATP-sensitive potassium ion (KATP) channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2758ddf0e6e998ed71af46590d47a744
https://doi.org/10.1210/en.2018-00419
https://doi.org/10.1210/en.2018-00419