Zobrazeno 1 - 10
of 441
pro vyhledávání: '"CAMP-SPECIFIC PHOSPHODIESTERASE"'
Autor:
Jos Prickaerts, Melissa Schepers, Tim Vanmierlo, Ben Rombaut, Dean Paes, Daniel L.A. van den Hove
Publikováno v:
Pharmacological Reviews. 73:1016-1049
The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5445a4a14915242d7041cdc62d2a31
https://doi.org/10.1124/pharmrev.120.000273
https://doi.org/10.1124/pharmrev.120.000273
Publikováno v:
Pharmacological Reviews. 73(3):1016-1049
The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::87a092425e11a76f44f5b9a0dea66f59
https://doi.org/10.1124/pharmrev.120.000273
https://doi.org/10.1124/pharmrev.120.000273
Akademický článek
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Publikováno v:
Neuroscience and Biobehavioral Reviews. 113:12-38
A plethora of studies indicate the important role of cAMP and cGMP cascades in neuronal plasticity and memory function. As a result, altered cyclic nucleotide signaling has been implicated in the pathophysiology of mnemonic dysfunction encountered in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::b66a18f52da2997fdc32cbf0b24a09de
https://doi.org/10.1016/j.neubiorev.2020.02.004
https://doi.org/10.1016/j.neubiorev.2020.02.004
Publikováno v:
Neuroscience and Biobehavioral Reviews. 113:12-38
A plethora of studies indicate the important role of cAMP and cGMP cascades in neuronal plasticity and memory function. As a result, altered cyclic nucleotide signaling has been implicated in the pathophysiology of mnemonic dysfunction encountered in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d12e1c4c786fbc6784ab40329b719f
https://doi.org/10.1016/j.neubiorev.2020.02.004
https://doi.org/10.1016/j.neubiorev.2020.02.004
Autor:
Isabella Cattani-Cavalieri, Haoxiao Zuo, Viacheslav O. Nikolaev, Martina Schmidt, Nshunge Musheshe
Publikováno v:
Pharmacology & Therapeutics, 197, 225-242. PERGAMON-ELSEVIER SCIENCE LTD
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect millions of people all over the world. Cyclic adenosine monophosphate (cAMP) which is one of the most important second messengers, plays a vital rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a26252049dc7765b65ece4c82a055e
https://hdl.handle.net/11370/4a095875-e9b2-45fb-affa-e338106dd794
https://hdl.handle.net/11370/4a095875-e9b2-45fb-affa-e338106dd794
Akademický článek
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Autor:
Tim Vanmierlo, Katie Lunnon, Dean Paes, Diego Mastroeni, Janou A. Y. Roubroeks, Daniel L.A. van den Hove, Ehsan Pishva, Elaine Delvaux, Paul D. Coleman, Roy Lardenoije, Melissa Schepers, Riccardo M. Carollo, Jos Prickaerts
Publikováno v:
Neurobiology of Aging, 97, 56-64. Elsevier Science
Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic potential to restore memory function in Alzheimer's disease (AD), but will likely evoke adverse side effects. As PDE4D encodes multiple isoforms, targeting specific isoforms ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5700354515d40386a8c31e7384e6587
http://hdl.handle.net/1942/33241
http://hdl.handle.net/1942/33241
Autor:
Gencer Sancar, Sihao Liu, Emanuel Gasser, Jacqueline G. Alvarez, Christopher Moutos, Kyeongkyu Kim, Tim van Zutphen, Yuhao Wang, Timothy F. Huddy, Brittany Ross, Yang Dai, David Zepeda, Brett Collins, Emma Tilley, Matthew J. Kolar, Ruth T. Yu, Annette R. Atkins, Theo H. van Dijk, Alan Saghatelian, Johan W. Jonker, Michael Downes, Ronald M. Evans
Publikováno v:
Cell Metab
Cell metabolism, 34(1), 171-183.E6. CELL PRESS
Cell metabolism, 34(1), 171-183.E6. CELL PRESS
Inexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously, we showed that peripheral delivery of exogenous fibroblast growth factor 1 (FGF1) has robust anti-diabetic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830a4346330bd93206e8219bfa472963
https://hdl.handle.net/11370/b5fac37b-87e5-4748-a768-58576879b579
https://hdl.handle.net/11370/b5fac37b-87e5-4748-a768-58576879b579
Akademický článek
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