Zobrazeno 1 - 10
of 1 260
pro vyhledávání: '"CAMK"'
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 3461-3476 (2024)
Yu-Qing Tan,1,* Wang Zhang,2,* Zi-Cong Xie,1 Jun Li,1 Heng-Wen Chen3 1Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, People’s Republic of China; 2Department of Pharmacy, Guang
Externí odkaz:
https://doaj.org/article/839fa245c5a9486fb73511218c86fd80
Publikováno v:
Translational Neuroscience, Vol 15, Iss 1, Pp 2-10 (2024)
Calmodulin-dependent protein kinases (CaMKs) are widely regarded as “memory molecules” due to their role in controlling numerous neuronal functions in the brain, and the CaMK signaling pathway plays a crucial role in controlling synaptic plastici
Externí odkaz:
https://doaj.org/article/f30335edea0f4a19bac91df403d18464
Autor:
Mingqiang Zeng, Zhiwei Zhu, Wuxiong Yuan, Zhengyan Tang, Zhibiao Qing, Qiang Lu, Xuecheng Wu, Junhuan He, Yuanwei Li, Zhuo Li
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Background Ureteral stricture (US) is a pathological stenosis in the urinary tract characterized by increased collagen synthesis and inflammation. Autophagy activation has been shown to ameliorate tissue fibrosis and protect against fibrotic diseases
Externí odkaz:
https://doaj.org/article/011a7ecaa36e42b6a729d37ee7f91e84
Autor:
Niyati Parekh, Sarthak Lakhani, Ayushi Patel, Dhyanesh Oza, Bhumika Patel, Ruchi Yadav, Udit Chaube
Publikováno v:
Artificial Intelligence Chemistry, Vol 1, Iss 2, Pp 100009- (2023)
In the present research, a few well-known artificial intelligence tools were explored for efficient hit selection which could be further utilized for the discovery of CaMK-II inhibitors for the Treatment of arrhythmia. To achieve the desired goals ph
Externí odkaz:
https://doaj.org/article/3b86ba3277644431b00da06721280f28
Publikováno v:
Brain Research Bulletin, Vol 202, Iss , Pp 110724- (2023)
Background: Ketamine, despite its efficacy in treating depression, raises concerns regarding safety due to potential abuse, cognitive impairment, and bladder toxicity. Ketamine can affect the locus coeruleus (LC) norepinephrine and attention networks
Externí odkaz:
https://doaj.org/article/ca36ddc89b4a48408776e0c4ebf75509
Autor:
Nada Al-Saran, Pandurangan Subash-Babu, Laila Naif Al-Harbi, Bahauddeen M. Alrfaei, Ali A. Alshatwi
Publikováno v:
Nanomaterials, Vol 14, Iss 2, p 199 (2024)
The primary pathological hallmark of Alzheimer’s disease (AD) is the formation and accumulation of neurofibrillary tangles and plaques, which result from the aggregation of amyloid-β (Aβ) induced by oxidative stress. The effectiveness of Alzheime
Externí odkaz:
https://doaj.org/article/b0aea7901aca483b873eb18170615cc8
Publikováno v:
Journal of Functional Foods, Vol 96, Iss , Pp 105211- (2022)
Allergy is considered a hyperreactive immune response. Oligosaccharide ingredients are often incorporated in dietary supplements to modulate immunity, with oligosaccharides in ginseng thought to exert beneficial immunoregulatory effects. Here, effica
Externí odkaz:
https://doaj.org/article/71c3e99c844f42038d52a89808725644
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Autor:
Xi Wang, Kang Xiao, Guang-Zhen Jiang, Yong-Jun Dai, Kenneth Abasubong, Hui-Xing Guo, Mang-Mang Wang, Xiang-Fei Li, Ding-Dong Zhang, Wen-Bin Liu
Publikováno v:
Aquaculture Reports, Vol 24, Iss , Pp 101127- (2022)
The study aimed to investigate the effects of four fatty acids with the same carbon-chain length and different saturations, stearic acid (SA), oleic acid (OA), linoleic acid (LA), and linolenic acid (LNA), on the growth performance and muscle quality
Externí odkaz:
https://doaj.org/article/44790ba4c2274b4a8e9d978352144e58
Autor:
Qi Guo, Emi Kouyama-Suzuki, Yoshinori Shirai, Xueshan Cao, Toru Yanagawa, Takuma Mori, Katsuhiko Tabuchi
Publikováno v:
Cells, Vol 12, Iss 8, p 1177 (2023)
Microcephaly with pontine and cerebellar hypoplasia (MICPCH) syndrome is a neurodevelopmental disorder caused by the deficiency of the X-chromosomal gene CASK. However, the molecular mechanisms by which CASK deficiency causes cerebellar hypoplasia in
Externí odkaz:
https://doaj.org/article/65c5aa1e4d2b4023b26efdea77ba4b13