Adipose Triglyceride Lipase Loss Promotes a Metabolic Switch in A549 Non-Small Cell Lung Cancer Cell Spheroids

Autor: Sophie, Honeder, Tamara, Tomin, Laura, Nebel, Jürgen, Gindlhuber, Katarina, Fritz-Wallace, Maximilian, Schinagl, Christoph, Heininger, Matthias, Schittmayer, Nassim, Ghaffari-Tabrizi-Wizsy, Ruth, Birner-Gruenberger

Publikováno v: Molecular & Cellular Proteomics : MCP

Cancer cells undergo complex metabolic adaptations to survive and thrive in challenging environments. This is particularly prominent for solid tumors, where cells in the core of the tumor are under severe hypoxia and nutrient deprivation. However, su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29d3b9b68dc7ed18d3b4083dd33e660a
https://pubmed.ncbi.nlm.nih.gov/33992777

FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway1

Autor: Tornin, Juan, Hermida-Prado, Francisco, Padda, Ranjit Singh, Gonzalez, M. Victoria, Alvarez-Fernandez, Carlos, Rey, Veronica, Martinez-Cruzado, Lucia, Estupiñan, Oscar, Menendez, Sofia T., Fernandez-Nevado, Lucia, Astudillo, Aurora, Rodrigo, Juan P., Lucien, Fabrice, Kim, Yohan, Leong, Hon S., Garcia-Pedrero, Juana Maria, Rodriguez, Rene

Publikováno v: Neoplasia (New York, N.Y.)

Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bee4cd4a7bbc6de7e2a60b6a0c9b8e2
http://europepmc.org/articles/PMC5747526

The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line

Autor: Dong-Mei Wang, Hui Ge, Shihui Liang, Heng Liu, Jia-Hui Liu, Mei-Gui Lin, Yue-Yu Gu, Sui-Lin Mo, Jun Xie, Tao-Li Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 5, Iss 6, Pp 554-563 (2015)
Acta Pharmaceutica Sinica. B

The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated. The exploration of the interaction between tanshinone IIA and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6d686d54b20dbd41fb25d42b354513
https://doi.org/10.1016/j.apsb.2015.07.008

Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis

Autor: Toshiya Nakamura, Hiroyuki Nozaka, Ikuko Kakizaki, Takashi Kobayashi

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 72-78 (2017)

Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues. Chondroitin sulfate proteoglycans (CSPGs) are a major extracellular component in cartilag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b375768d8a0a94313ec69701238e816c
https://pubmed.ncbi.nlm.nih.gov/28955991

In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane

Autor: Malathi Ragunathan, Reji Manjunathan

Publikováno v: Biological Research, Volume: 48, Pages: 1-13, Published: 2015
Biological Research
Biological Research, Vol 48, Iss 0, Pp 1-13 (2015)
Biological Research v.48 2015
SciELO Chile
CONICYT Chile
instacron:CONICYT

BACKGROUND: Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogenesis through binding to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde8079e6e52928271c148c80acf3ab3
https://doi.org/10.1186/s40659-015-0021-z