Zobrazeno 1 - 10
of 1 282
pro vyhledávání: '"CALR"'
Autor:
Dong Jingting, Kang Shaosan, Cao Fenghong, Chen Xi, Wang Xiaofei, Wang Lei, Wang Qing, Zhai Yupu
Publikováno v:
Open Life Sciences, Vol 19, Iss 1, Pp 209-49 (2024)
Calcium homeostasis is correlated closely with the occurrence and development of various cancers. The role of calcium homeostasis in prostate cancer has remained unclear. The present study aimed to investigate the relationship between transmembrane a
Externí odkaz:
https://doaj.org/article/07badb8423f9496eb677789bbf28b602
Autor:
Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka, Burkhart Schraven, Anthony R. Green, Andreas J. Müller, Dimitrios Mougiakakos, Thomas Fischer
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-23 (2024)
Abstract Background Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-programs the function
Externí odkaz:
https://doaj.org/article/de0cb7b1744d4527b1c4f8287f2223f4
Autor:
Velizar Shivarov, Gergana Tsvetkova, Ilina Micheva, Evgueniy Hadjiev, Jasmina Petrova, Anela Ivanova, Galia Madjarova, Milena Ivanova
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
It has been demonstrated previously that human leukocyte antigen class I (HLA-I) and class II (HLA-II) alleles may modulate JAK2 V617F and CALR mutation (CALRmut)-associated oncogenesis in myeloproliferative neoplasms (MPNs). However, the role of imm
Externí odkaz:
https://doaj.org/article/6a6deca4d4ff4b769557a724354ad0e5
Publikováno v:
eJHaem, Vol 5, Iss 2, Pp 392-396 (2024)
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) results from the loss of erythrocyte surface proteins, leading to complement activation and its spectrum of effects. We explore this case of a 57‐year‐old man with post‐essential thrombocythemi
Externí odkaz:
https://doaj.org/article/5fb4bdd737b5435ebb964f5cb4be3487
Autor:
Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin Böttcher, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß, Thomas Fischer
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via calcium release-activated calcium (CRAC) channels represents a major pa
Externí odkaz:
https://doaj.org/article/db493b9498e045b9a9db0c8fc03508d6
Autor:
Zehra Narlı Özdemir, Yıldız İpek, Püsem Patır, Gözde Ermiş, Rafiye Çiftçiler, Deniz Özmen, Mehmet Baysal, Vildan Gürsoy, Esra Yıldızhan, Serkan Güven, Tarık Ercan, Tayfun Elibol, Sinan Mersin, Eylem Genç, Eren Arslan Davulcu, Volkan Karakuş, Nergiz Erkut, Gürsel Güneş, Reyhan Diz Küçükkaya, Ahmet Emre Eşkazan
Publikováno v:
Turkish Journal of Hematology, Vol 41, Iss 1, Pp 26-36 (2024)
Objective: In this study, we investigated the effects of calreticulin (CALR) and JAK2V617F mutational status on clinical course and disease outcomes in Turkish patients with essential thrombocythemia (ET). Materials and Methods: Seventeen centers fr
Externí odkaz:
https://doaj.org/article/ab5f757b27aa42b59fc159ec0b70c9e6
Autor:
Mostafa Najim, Mohammad Abu-Tineh, Awni Alshurafa, Mohamed Izham Mohamed Ibrahim, Soubiya Ansari, Hazem Faraj, Saif Alateeg, Susanna Jane Akiki, Mohamed A. Yassin
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
ABSTRACTBackground Myeloproliferative neoplasms (MPNs) are hematological disorders characterized by abnormal production of myeloid cells due to genetic mutations. Since 2013, researchers have identified somatic mutations in the Calreticulin (CALR) ge
Externí odkaz:
https://doaj.org/article/8fad399548d140829ec749fe345f77c6
Autor:
Massimo Breccia, Francesca Palandri, Nicola Polverelli, Morena Caira, Michela Berluti, Giuseppe A. Palumbo, Valerio De Stefano
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Myelofibrosis (MF) is a clonal disorder of hematopoietic stem cells characterized by altered bone marrow function and fibrosis. The aim of this narrative review is to report on the most recent epidemiologic data and to discuss features of MF and curr
Externí odkaz:
https://doaj.org/article/e80da66563fb478dbd2e047a3b4200e5
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/f73926f7c9a143148108f3c2b0d617ae
Autor:
Magda Zanelli, Valentina Fragliasso, Giuseppe Gaetano Loscocco, Francesca Sanguedolce, Giuseppe Broggi, Maurizio Zizzo, Andrea Palicelli, Stefano Ricci, Elisa Ambrogi, Giovanni Martino, Sara Aversa, Francesca Coppa, Pietro Gentile, Fabrizio Gozzi, Rosario Caltabiano, Nektarios Koufopoulos, Aleksandra Asaturova, Luca Cimino, Alberto Cavazza, Giulio Fraternali Orcioni, Stefano Ascani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Myeloproliferative neoplasms (MPNs) are subdivided into Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) and Ph-negative MPNs. BCR::ABL1 translocation is essential for the development and diagnosis of CML; on the other hand, the m
Externí odkaz:
https://doaj.org/article/4fe0b9b39cf248c7a452aedee928a312