Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells

Autor: Marisela Rodriguez, Jiyuan Chen, Pritesh P. Jain, Aleksandra Babicheva, Mingmei Xiong, Jifeng Li, Ning Lai, Tengteng Zhao, Moises Hernandez, Angela Balistrieri, Sophia Parmisano, Tatum Simonson, Ellen Breen, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y. -J. Shyy, Jian Wang, Joe G. N. Garcia, Ayako Makino, Jason X. -J. Yuan

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscularization in

Externí odkaz: https://doaj.org/article/1995a8a050974260b9221a472c8505e7

Cryo-EM structures and functional properties of CALHM channels of the human placenta

Autor: Zaugg Jonas, Katarzyna Drożdżyk, Raimund Dutzler, Marta Sawicka, Christiane Albrecht, Dawid Deneka, Maria-Isabel Bahamonde-Santos

Publikováno v: eLife
eLife, Vol 9 (2020)
Drożdżyk, Katarzyna; Sawicka, Marta; Bahamonde-Santos, Maria-Isabel; Zaugg, Jonas; Deneka, Dawid; Albrecht, Christiane; Dutzler, Raimund (2020). Cryo-EM structures and functional properties of CALHM channels of the human placenta. eLife, 9 eLife Sciences Publications 10.7554/eLife.55853

The transport of substances across the placenta is essential for the development of the fetus. Here, we were interested in the role of channels of the calcium homeostasis modulator (CALHM) family in the human placenta. By transcript analysis, we foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc53bf1c247dfc2c3e53e7d1fc3dbee
https://www.zora.uzh.ch/id/eprint/188726/

Cryo-EM structures and functional properties of CALHM channels of the human placenta.

Autor: Drożdżyk K; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Sawicka M; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Bahamonde-Santos MI; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Jonas Z; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland., Deneka D; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Albrecht C; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland., Dutzler R; Department of Biochemistry, University of Zurich, Zurich, Switzerland.

Publikováno v: ELife [Elife] 2020 May 06; Vol. 9. Date of Electronic Publication: 2020 May 06.