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Restricted Presence of POU6F2 in Human Corneal Endothelial Cells Uncovered by Extension of the Promoter-level Expression Atlas

Autor: Yoshihide Hayashizaki, Masayoshi Itoh, Masahito Yoshihara, Motokazu Tsujikawa, Kohji Nishida, Hideya Kawaji, Susumu Hara, Satoshi Kawasaki

Publikováno v: EBioMedicine, Vol 25, Iss C, Pp 175-186 (2017)
EBioMedicine

Corneal endothelial cells (CECs) are essential for maintaining the clarity of the cornea. Because CECs have limited proliferative ability, interest is growing in their potentially therapeutic regeneration from pluripotent stem cells. However, the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed12cd6308a474dd4458e16b740349a1
https://doi.org/10.1016/j.ebiom.2017.10.024

Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions

Autor: Margaret R, Davis, Erik, Arner, Cairnan R E, Duffy, Paul A, De Sousa, Ingrid, Dahlman, Peter, Arner, Kim M, Summers

Publikováno v: Molecular Genetics and Metabolism

Fibrillin-1 is a large glycoprotein encoded by the FBN1 gene in humans. It provides strength and elasticity to connective tissues and is involved in regulating the bioavailability of the growth factor TGFβ. Mutations in FBN1 may be associated with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e89461939fb86dc00b684edfc06606c9
https://pubmed.ncbi.nlm.nih.gov/27386756

Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1

Autor: Tracey L. Purvis, Karen Piper Hanley, Neil A. Hanley, Tom Hearn, Cosma Spalluto, David I. Wilson, Victoria J. Knorz, Tilman Sanchez-Elsner

Publikováno v: Gene

Mutations in the human gene ALMS1 cause Alström syndrome, a disorder characterised by neurosensory degeneration, metabolic defects and cardiomyopathy. ALMS1 encodes a centrosomal protein implicated in the assembly and maintenance of primary cilia. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7364927d2dc392987d5275b8098eb4

Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions.

Autor: Kojima Y; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Tsuchiya A; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Ogawa M; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Nojiri S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Takeuchi S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Watanabe T; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Nakajima K; Research Laboratory, Nihon Pharmaceutical Co Ltd, 34 Shin-izumi, Narita-City, Chiba, 286-0825, Japan., Hara Y; Research Laboratory, Nihon Pharmaceutical Co Ltd, 34 Shin-izumi, Narita-City, Chiba, 286-0825, Japan., Yamashita J; Research Laboratory, Nihon Pharmaceutical Co Ltd, 34 Shin-izumi, Narita-City, Chiba, 286-0825, Japan., Kikuta J; Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan., Takamura M; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan., Ishii M; Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan., Terai S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.

Publikováno v: Regenerative therapy [Regen Ther] 2019 Sep 20; Vol. 11, pp. 269-281. Date of Electronic Publication: 2019 Sep 20 (Print Publication: 2019).