Zobrazeno 1 - 10
of 41
pro vyhledávání: '"CAFs, cancer associated fibroblasts"'
Autor:
Dan Liang, Lu Liu, Yunjie Zhao, Zhenyi Luo, Yadi He, Yanping Li, Shiyun Tang, Jianyuan Tang, Nianzhi Chen
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell signaling in ECM remodeling contribute to uncontrolled proliferation,
Externí odkaz:
https://doaj.org/article/a3e4008dbd7746c8ae99bcf743fbeaef
Autor:
Yihui Yang, Xiangjin Zheng, Sha Li, Jinyi Liu, Wan Li, Jie Yi, Weiqi Fu, Jinhua Wang, Guanhua Du, Liwen Ren
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2783-2797 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfeee0d62636797c4da5264a84ca925
https://doi.org/10.1016/j.apsb.2021.01.001
https://doi.org/10.1016/j.apsb.2021.01.001
Autor:
Guolong Liao, Hanqi Lei, Xiangwei Yang, Xing Fu, Fu Shi, Donggen Jiang, Haiyun Xiong, Yafei Yang, Yu-Peng Feng, Jun Pang, Bing-Biao Lin
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4941-4953 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4941-4953 (2021)
Graphical abstract
MicroRNA (miRNA) deregulation plays a critical role in the heterogeneous development of prostate cancer (PCa) by tuning mRNA levels. Herein, we aimed to characterize the molecular features of PCa by clustering the miRNA-regula
MicroRNA (miRNA) deregulation plays a critical role in the heterogeneous development of prostate cancer (PCa) by tuning mRNA levels. Herein, we aimed to characterize the molecular features of PCa by clustering the miRNA-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f138460d0ba30547d9145ec00105384e
http://europepmc.org/articles/PMC8433071
http://europepmc.org/articles/PMC8433071
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e3a12774af1e45fb188f205ad9bdc
https://doi.org/10.1016/j.bioactmat.2020.12.010
https://doi.org/10.1016/j.bioactmat.2020.12.010
Autor:
Xian Zeng, Dianwen Ju, Jiajun Fan, Yichen Wang, Jinghui Zhang, Jingyun Luan, Kai Yin, Mingming Nie
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 609-620 (2021)
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9591fe5f71a6d93ff75c586983adcb
https://doi.org/10.1016/j.apsb.2020.10.022
https://doi.org/10.1016/j.apsb.2020.10.022
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 55-70 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa624bee1b295d3b2a8ea11ea5504c8
http://www.sciencedirect.com/science/article/pii/S2211383520307322
http://www.sciencedirect.com/science/article/pii/S2211383520307322
Autor:
Kenji Izumi, Nyein Nyein Chan, Jun-ichi Tanuma, Satoshi Maruyama, Kenta Haga, Masami Kawaharada, Manabu Yamazaki, Ayako Suzuki, Toshihiko Mikami, Tadaharu Kobayashi, Emi Hoshikawa, Akinori Funayama
Publikováno v:
Translational Oncology, Vol 14, Iss 12, Pp 101236-(2021)
Translational Oncology
Translational Oncology
Highlights • TGF-β1 secreted from CAFs promote the migration and invasion of OSCC cells. • CAFs upregulate SOX9 expression of OSCC cells, possibly through inducing EMT. • The presence of CAFs is correlated with SOX9 expression in the invasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37e513d06f9e4f0bfec369f2e664e8f
http://www.sciencedirect.com/science/article/pii/S193652332100228X
http://www.sciencedirect.com/science/article/pii/S193652332100228X
Autor:
Bingji Li, Wei Yin, Ying-Hong Shi, Yuli Lin, Yan Song, Qian Cai, Haoyang Luo, Xuguang Yang, Wei-Ren Liu, Rui He, Meng-Xin Tian
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 12, Pp 1133-1142 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Desmoplasia is a hallmark of intrahepatic cholangiocarcinoma (ICC), which constitutes a barrier to infiltration of lymphocyte, but not myeloid cells. Given that dense desmoplastic stroma has been reported to be a barrier to infiltration of lymphocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d6c0ce901e4672be0f59c5e42bd8a5
https://doi.org/10.1016/j.neo.2019.10.005
https://doi.org/10.1016/j.neo.2019.10.005
Autor:
Adam Hermawan, Herwandhani Putri
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Background Glioblastoma is one of the most aggressive and deadliest malignant tumors. Acquired resistance decreases the effectiveness of bevacizumab in glioblastoma treatment and thus increases the mortality rate in patients with glioblastoma. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4519cbb662dda7f536317ea5c1279b4
https://pubmed.ncbi.nlm.nih.gov/34819791
https://pubmed.ncbi.nlm.nih.gov/34819791
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 692-703 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 692-703 (2021)
Cancer-associated fibroblasts cells (CAFs) confer a rapid growth and metastasis ability of endometrial cancer (EC) via exosomes-mediated cellular communication. Long non-coding RNA nuclear enriched abundant transcript 1 (lncRNA NEAT1) drives the mali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b499990be0d892ecc3247d43ec0a7c3b
https://pubmed.ncbi.nlm.nih.gov/34153644
https://pubmed.ncbi.nlm.nih.gov/34153644