Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma

Autor: Junqi He, Ying Yang, Duiping Feng, Junfang Zheng, Zhiqiang Peng, Lei Wang

Publikováno v: EBioMedicine
EBioMedicine, Vol 15, Iss C, Pp 62-72 (2017)

Clear cell renal cell carcinoma (ccRCC) is the most lethal neoplasm of the urologic system. Clinical therapeutic effect varies greatly between individual ccRCC patients, so there is an urgent need to develop prognostic molecular biomarkers to help cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8f64b5502a35e2b61a2a5b14ba4d22
https://doi.org/10.1016/j.ebiom.2016.12.003

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

Autor: Ronald T. Hay, Patrick G. A. Pedrioli, Adel F. M. Ibrahim, John S. Bett, Amit K. Garg, Sonia Rocha, Van Kelly

Publikováno v: Biochemical Journal

HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe9595871df7ee3d6e3a8d7fdf77458
https://pubmed.ncbi.nlm.nih.gov/23398456

miR-7/TGF- β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis.

Autor: Su T; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Huang S; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Zhang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Guo Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Zhang S; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Guan J; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Meng M; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Liu L; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Wang C; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Yu D; Department of Molecular and Cellular Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kwan HY; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China., Huang Z; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Huang Q; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Lai-Han Leung E; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR) 999078, China., Hu M; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA., Wang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Liu Z; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR) 999078, China., Lu L; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR) 999078, China.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 Feb; Vol. 12 (2), pp. 821-837. Date of Electronic Publication: 2021 Jun 17.